Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patient

Last updated: May 23, 2025
Sponsor: Centre Hospitalier Universitaire de Nīmes
Overall Status: Active - Recruiting

Phase

N/A

Condition

Kidney Disease

Hemodialysis

Kidney Failure

Treatment

CVVHD Dialysis parameters

CVVHDF Dialysis parameters

Clinical Study ID

NCT06369064
2023A02707-38
  • Ages > 18
  • All Genders

Study Summary

In patients requiring renal replacement therapy (RRT) in the intensive care unit (ICU), continuous techniques are predominantly using due to better hemodynamic tolerance. The most employed techniques in ICU are continuous venovenous hemodiafiltration (CVVHDF) and continuous venovenous hemodialysis (CVVHD).

To our knowledge, there are no prospective studies comparing the efficiency of these two techniques with the same dose of dialysis (and the same filter).

In the CompEER study, we aim to compare the efficiency of CVVHD and CVVHDF on urea reduction rate in intensive care patients with acute kidney injury.

The research hypothesis is that CVVHD citrate technique is as effective as CVVHDF heparin technique for urea reduction and provides prolonged and stable clearance, facilitating antibiotic management during RRT.

Eligibility Criteria

Inclusion

Inclusion criteria:

  • Adult patients hospitalized in ICU

  • Undergo RRT session because of AKI stage 3

  • At least one among criteria: pH < 7,20 / Blood urea > 30mM / Fluid overloaduncontrolled by diuretics.

  • Patient having given free and informed consent, and having signed the consent formor patient included in an emergency situation

  • Patient affiliated with Social Security.

Exclusion

Exclusion criteria:

  • End-stage chronic kidney disease on dialysis

  • Intoxication with a dialyzable toxin (lithium

  • Criteria for emergency dialysis initiation: hyperkaliemia >6,5mM withelectrocardiographic signs

  • Medical contraindication to regional citrate: severe liver failure

  • Medical contraindication to anticoagulation or heparin anticoagulation: heparininduced thrombopenia or uncontrolled bleeding

  • Pregnant women, parturient or breast-feeding patient

Study Design

Total Participants: 80
Treatment Group(s): 2
Primary Treatment: CVVHD Dialysis parameters
Phase:
Study Start date:
July 03, 2024
Estimated Completion Date:
August 15, 2026

Study Description

Acute Kidney Injury (AKI) is found in more than 50% of intensive care unit (ICU) patients, with 30% classified as AKI Network (AKIN) stage 3. Approximately 23% of AKI patients undergo RRT, predominantly utilizing continuous techniques due to better hemodynamic tolerance in unstable patients. Common continuous RRT techniques include continuous venovenous hemofiltration (CVVH), continuous venovenous hemodialysis (CVVHD), and continuous venovenous hemodiafiltration (CVVHDF).

The two most employed techniques in ICU are CVVHDF and CVVHD. However, the choice often depends on institutional practices rather than scientific evidence. Limited studies comparing these techniques at equivalent doses exist, and French recommendations allow intensivists discretion based on availability and team experience. A small, randomized study comparing different exchange rates found higher urea reduction in CVVHDF but lacked statistical significance. Current practices in ICU involve using CVVHDF with systemic anticoagulation or CVVHD with regional citrate anticoagulation based on practitioner preferences.

Despite potential benefits of CVVHD with citrate, such as extended filter lifespan and stable dialysis dose, the impact on concomitant treatments, especially antibiotics, needs consideration.

The study aims to demonstrate the non-inferiority of citrate-based continuous hemodialysis (CVVHD) compared to heparin-based continuous hemodiafiltration (CVVHDF) in terms of urea reduction rate at 24 hours in AKI patients requiring renal replacement therapy.

The hypothesis is that CVVHD citrate is as effective as CVVHDF heparin, providing prolonged and stable clearance, facilitating antibiotic management during RRT.

Connect with a study center

  • CHU de Nimes

    Nîmes, 30029
    France

    Active - Recruiting

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