The Acute T-Rex (Timing of Resistance Exercise) Study

Last updated: April 1, 2025
Sponsor: University of Utah
Overall Status: Active - Recruiting

Phase

N/A

Condition

Diabetes Mellitus, Type 2

Obesity

Narcolepsy

Treatment

Resistance Exercise Timing

Clinical Study ID

NCT06366399
00156659
  • Ages 50-74
  • All Genders

Study Summary

The primary aim of this study is to evaluate if a single bout of AM vs PM resistance exercise has different effects on insulin sensitivity and sleep. A randomized cross-over trial be used to compare resistance exercise at two different times of the day. Each condition will take place in a laboratory setting. Each condition will consist of exercise, overnight sleep, and oral glucose tolerance tests the following day. The AM exercise will occur ~1.5 hours after habitual wake, and PM exercise will occur ~11 hours after habitual wake. After a 2-6 week washout, participants will complete the other condition. The hypothesis is that PM exercise will be more beneficial than AM exercise in improving insulin sensitivity. This study could identify if there is a better time of day to perform resistance exercise to decrease risk of developing Type 2 Diabetes Mellitus.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Men and women, all ethnicities, aged 50-74 years

  • BMI ≥25 kg/m² and <45 kg/m²

  • Weight stable (less than 5% change in the past 6 months)

  • Generally healthy individuals

  • Not meeting recommended activity guidelines for aerobic or resistance exercise

Exclusion

Exclusion Criteria:

  • Uncontrolled cardiovascular, metabolic, renal, or pulmonary disease

  • Cancer treatment in the past 5 years

  • Untreated thyroid disease or other medical conditions affecting weight or energymetabolism

  • Current use of weight loss medication or other medications likely to impact energybalance

  • Bariatric surgery or extensive bowel resection in the past 2 years

  • Current or recent history (past 2 years) of eating disorder

  • Diagnosis of insomnia, sleep apnea, or other sleep and circadian disorders

  • Non-English speaking

  • HbA1c >6.5%

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: Resistance Exercise Timing
Phase:
Study Start date:
November 15, 2023
Estimated Completion Date:
December 31, 2025

Connect with a study center

  • University of Utah HPER E Buildling

    Salt Lake City, Utah 84112
    United States

    Active - Recruiting

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