Re-Purposing the Ordering of Routine Laboratory Tests in Hospitals in British Columbia

Last updated: November 28, 2025
Sponsor: University of British Columbia
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Laboratory test overuse (LTO) Bundle

Clinical Study ID

NCT06359587
H22-03005
  • Ages > 18
  • All Genders

Study Summary

The goal of this stepped-wedge cluster randomized trial is to assess the impact of a laboratory test overuse intervention bundle on laboratory test utilization in 6 health authorities (16 hospitals) in British Columbia. The main question it aims to answer is if the intervention bundle, inclusive of healthcare provider and patient engagement tools, can be effectively implemented for hospitalized medical inpatients in 16 hospitals across BC and reduce laboratory test over-use. Researchers will compare hospital clusters that receive the intervention at different (sequential) time points to see if there are significant changes in the measured outcomes after the intervention.

Eligibility Criteria

Inclusion

Participants involved in this study include the following groups: patients and healthcare providers (including learners, physicians and allied health staff)

Inclusion Criteria:

  • Patients: The study will include all adult general medical patients that areadmitted to the selected hospital during the study period under general internalmedicine or family medicine (hospitalist) provider groups.

  • Attending Physicians: All physicians who provide patient care in the generalinternal medicine or family medicine (hospitalist) provider groups in selectedhospitals

  • Learners and allied health staff (Medical Students/Resident physicians/ClinicalAssistants/ Nurse Practitioners, etc.): All those who help take care of patients andcan order labs during the study period in the under general internal medicine orfamily medicine (hospitalist) provider groups in selected hospitals The date rangefor both groups will extend from May 2024 until study completion in October 2026.

Exclusion

Exclusion Criteria:

  • Patients: all patients in specialized medical units (e.g., coronary care, dialysisunits, bone marrow transplants units etc.), in critical care, pediatric,obstetrical, surgical, and psychiatric units.

  • Patients and Health Care Providers (HCPs) who are not in the internal medicine orfamily medicine groups

Study Design

Total Participants: 700000
Treatment Group(s): 1
Primary Treatment: Laboratory test overuse (LTO) Bundle
Phase:
Study Start date:
May 06, 2024
Estimated Completion Date:
November 16, 2026

Study Description

This study aims to reduce unnecessary laboratory test use in hospitals using a stepped-wedge cluster randomized trial design. Over-use of laboratory testing in hospitals leads to patient discomfort, disruption of sleep patterns, and is associated with hospital-acquired anemia. The specific tests that the investigators focus on are complete blood count, electrolytes, creatinine, urea, international normalized ratio and partial thromboplastin time. After the initial control period, the investigators will begin with a pilot-phase for a feasibility assessment of the intervention tools. The intervention bundle will then be rolled out sequentially, one cluster (each cluster containing 2-3 hospitals) at a time in 12-week implementation steps.

The intervention bundle will contain tools to promote education around appropriate use of laboratory testing in hospitals (using an online module, clinical decision support tool), will share data on laboratory test utilization patterns locally, and include patient engagement materials (infographic and video).

Local champions in hospitals will form multidisciplinary implementation teams to facilitate adaptation and delivery of implementation tools within local context. A pragmatic stepped-wedge design will be used to implement the intervention bundle in 16 hospitals grouped into 8 clusters.

The first 4 weeks of implementation will be a pre-intervention period, trialing and adapting tools to the local context. Readiness assessments and workflow observations will be conducted to understand organizational readiness for implementation. Clusters will enter the intervention period during the latter 8 weeks of the implementation period where intervention tools will be deployed.

Data will be collected for at least 24 weeks post-implementation, evaluating the impact of tools without dedicated personnel support. Access to educational resources will continue, and laboratory utilization reports will be sent.

Connect with a study center

  • University Hospital of Northern British Columbia

    Prince George, British Columbia V2M 1S2
    Canada

    Site Not Available

  • Mount St. Joseph's Hospital

    Vancouver, British Columbia V5T3N4
    Canada

    Active - Recruiting

  • St. Paul's Hospital

    Vancouver, British Columbia V6Z 1Y6
    Canada

    Site Not Available

  • Vancouver General Hospital

    Vancouver, British Columbia V5Z1N1
    Canada

    Active - Recruiting

  • University Hospital of Northern British Columbia

    Prince George 6113365, British Columbia 5909050 V2M 1S2
    Canada

    Active - Recruiting

  • Mount St. Joseph's Hospital

    Vancouver 6173331, British Columbia 5909050 V5T3N4
    Canada

    Active - Recruiting

  • St. Paul's Hospital

    Vancouver 6173331, British Columbia 5909050 V6Z 1Y6
    Canada

    Active - Recruiting

  • Vancouver General Hospital

    Vancouver 6173331, British Columbia 5909050 V5Z1N1
    Canada

    Active - Recruiting

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