Propofol Versus Midazolam in Sedation for Upper and Lower Gastrointestinal Endoscopy.

Last updated: April 6, 2024
Sponsor: Mansoura University
Overall Status: Active - Recruiting

Phase

1

Condition

Ulcers

Gastrointestinal Diseases And Disorders

Treatment

Endoscopy

Clinical Study ID

NCT06358131
R.21.10.1493
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

There has been rapid growth in the number and complexity of gastrointestinal (GI) endoscopic procedures performed during the last decade. To ensure safe and effective upper GI endoscopy, the choice of an appropriate sedative agent is crucial. Sedation usually categorized into four stages: minimal, moderate, deep and general anesthesia. The upper gastrointestinal [GI] endoscopy usually performed under moderate sedation Sedation usually categorized into four stages: minimal, moderate, deep and general anesthesia. The upper gastrointestinal [GI] endoscopy usually performed under moderate sedation. Benzodiazepines still the most common sedative agents used for conscious sedation, either solely or in combination with opioids for upper GI endoscopy. Propofol is a hypnotic drug used for induction of anesthesia with short half-life that permits rapid patient recovery and discharge. Thus, its use is for upper GI endoscopy was adopted in many endoscopy centers. So we are going to Evaluate all adverse events related to anesthesia; in patients recruited for upper and lower endoscopy and compare between propofol and midazolam based anesthesia associated adverse events.Also we are going to Evaluate patient and endoscopist satisfaction as regarding propofol and midazolam anesthesia.

Eligibility Criteria

Inclusion

Inclusion Criteria: Age18 to 80 American Society of Anesthesiologists (ASA) class I-II Informed consent.Patients scheduled for upper and lower endoscopy.

Exclusion

Exclusion Criteria: Chronic use of drugs as benzodiazpines, neuroleptics and anticonvulsants for more than 30days. Hypersensitivity reactions to drugs used in the study. Psychiatric patients. Pregnancy.Being submitted to endoscopy as an emergency procedure.

Study Design

Total Participants: 656
Treatment Group(s): 1
Primary Treatment: Endoscopy
Phase: 1
Study Start date:
January 01, 2022
Estimated Completion Date:
August 01, 2024

Connect with a study center

  • Mansoura University

    Mansoura, Dakhlia 35516
    Egypt

    Active - Recruiting

  • MansouraU

    Mansoura,
    Egypt

    Active - Recruiting

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