Impact of Grape Powder Consumption on Eye Health and Glycemic Status in Singapore Older Adults

Last updated: November 12, 2024
Sponsor: National University of Singapore
Overall Status: Active - Recruiting

Phase

N/A

Condition

Aging

Treatment

Freeze-dried table grape powder

Placebo grape powder

Clinical Study ID

NCT06349304
S25
  • Ages 60-85
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to understand the impacts of regular consumption of freeze-dried table grape powder on eye health and regulation of advanced glycation end products in Singapore older adults. The investigators hypothesize that regular consumption of freeze-dried table grape powder will promote improvements in eye health and lower levels of advanced glycation end products when compared to the placebo group.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Male and female participants, aged between 60 and 85 years old inclusive

  2. English-literate and able to give informed consent in English

Exclusion

Exclusion Criteria:

  1. Smokers

  2. Allergy to grapes or food dyes/additives, or had serious food allergies in the past

  3. Known eye diseases (macular degeneration, cataracts, retinopathy or glaucoma),blindness in at least one eye or have had eye surgery

  4. Unable to view bright lights or flashing lights

  5. Has Type 1 or 2 diabetes, uremia, cardiovascular disease, abnormal kidney and liverfunction

  6. Taking eye medication and/or dietary supplements for the eyes for the past 3 month

  7. Taking supplements containing carotenoids (e.g. Vitamin A, lutein, zeaxanthin) forpast 3 months

  8. Currently on a specialised diet (e.g. vegetarian, vegan, weight loss diet, low fatdiet

  9. Consumes more than 2 alcoholic drinks per day i.e. one drink is defined as either 150ml of wine,340ml of beer/cider or 45ml of distilled spirit

  10. Significant change in weight (≥ 3 kg body weight) in the past 3 months

  11. Significant exercise pattern over the past 3 months defined as high-intensityexercise of more than 3 hours per week

  12. Currently on anti-hypertensive, cholesterol-lowering or psychoactive drugs

  13. Scored ≤ 7 on the abbreviated mental test

  14. Poor peripheral venous access based on past experiences with blood draw

  15. Participating in another clinical study

Study Design

Total Participants: 46
Treatment Group(s): 2
Primary Treatment: Freeze-dried table grape powder
Phase:
Study Start date:
September 30, 2024
Estimated Completion Date:
August 01, 2025

Study Description

The study will be a 16-week, double-blind, randomized, placebo-controlled trial using a parallel study design. 46 adults (aged 60 - 85) will be recruited and randomly assigned to the intervention or placebo group to investigate whether regular consumption of freeze-dried table grape powder (46g/d) can improve eye health parameters, blood/skin AGE and glycemic status, and reduce inflammation and oxidative stress. This study will consist of 1 screening visit and 5 study visits with 4-week intervals.

Connect with a study center

  • National University of Singapore, Faculty of Science, Department of Food Science and Technology

    Singapore, 117550
    Singapore

    Active - Recruiting

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