A Study of LY3841136 in Overweight and Obese Participants

Last updated: October 14, 2025
Sponsor: Eli Lilly and Company
Overall Status: Completed

Phase

1

Condition

Obesity

Hypertriglyceridemia

Diabetes Prevention

Treatment

LY3841136

Placebo

Tirzepatide

Clinical Study ID

NCT06345066
18834
J3R-MC-YDAC
  • Ages 18-65
  • All Genders

Study Summary

The main purpose of this study is to assess the safety and tolerability of LY3841136 when administered in combination with tirzepatide in overweight and obese patients. The study will last up to approximately 42 weeks.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Male and female participants who are overtly healthy as determined by medicalevaluation

  • Have a stable body weight and Body Mass Index in range of 27 to 45 kilogram permeter square (kg/m²).

  • Have clinical laboratory test results within normal reference range

  • Have venous access sufficient to allow for blood sampling

  • Are reliable and willing to make themselves available for the duration of the studyand are willing to follow study procedures

Exclusion

Exclusion Criteria:

  • Have type 1 or type 2 diabetes mellitus

  • Have an abnormal 12-lead electrocardiogram (ECG)

  • Have a history or presence of psychiatric disorders

  • Have abnormal blood pressure and pulse rate

  • Are currently enrolled in another clinical study trial involving medical research orhave participated within the last 30 days in a clinical study involving aninvestigational product.

Study Design

Total Participants: 96
Treatment Group(s): 3
Primary Treatment: LY3841136
Phase: 1
Study Start date:
April 03, 2024
Estimated Completion Date:
September 29, 2025

Connect with a study center

  • Fortrea CRU, Inc.

    Daytona Beach, Florida 32117
    United States

    Site Not Available

  • Fortrea Clinical Research Unit

    Daytona Beach, Florida 32117
    United States

    Site Not Available

  • Fortrea Clinical Research Unit

    Daytona Beach 4152872, Florida 4155751 32117
    United States

    Site Not Available

  • Fortrea CRU, Inc.

    Dallas, Texas 75247
    United States

    Site Not Available

  • Fortrea Clinical Research Unit

    Dallas, Texas 75247
    United States

    Site Not Available

  • Fortrea Clinical Research Unit

    Dallas 4684888, Texas 4736286 75247
    United States

    Site Not Available

  • Fortrea CRU, Inc.

    Madison, Wisconsin 53704
    United States

    Site Not Available

  • Fortrea Clinical Research Unit

    Madison, Wisconsin 53704
    United States

    Site Not Available

  • Fortrea Clinical Research Unit

    Madison 5261457, Wisconsin 5279468 53704
    United States

    Site Not Available

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