Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke

Last updated: March 27, 2024
Sponsor: The First Hospital of Hebei Medical University
Overall Status: Active - Recruiting

Phase

1/2

Condition

Memory Loss

Mild Cognitive Impairment

Blood Clots

Treatment

Pentoxifylline

Clinical Study ID

NCT06344390
20210327
  • Ages 40-80
  • All Genders

Study Summary

Pentoxifylline can improve cognitive impairment after ischemic stroke, possibly by improving the level of cerebral blood flow, affecting the content of blood oxygen and metabolic substances in the brain, and then playing a protective role in the transmission of nerve electrical signals, and ultimately improving cognitive function. The patients with cognitive impairment and non-dementia PSCIND after ischemic stroke were randomly divided into two groups. In addition to the basic drugs of ischemic stroke, the patients were given pentothemine sustained release tablets and blank control respectively to observe the effects of pentothemine on cognitive function and neuronal electrical signals in the patients with ischemic PSCIND. It is expected to explore the possible internal biological mechanism by using transcranial Doppler, oxygen-dependent functional magnetic resonance imaging and craniocerebral magnetic resonance pop analysis. Finally, statistical correlation analysis was used to elucidate the specific mechanism of pentoxifylline in improving cognitive function of non-dementia patients with cognitive impairment after ischemic stroke.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Han Chinese, age 40-80 years old, male and female, right-handed;
  • The diagnosis is consistent with the Expert Consensus on the Management of CognitiveImpairment after Stroke 2021;
  • NIHSS score 1-15 points;
  • Daily Living Ability Scale (ADL) ≥75 score;
  • The Informed consent signed by the patient or his legal representative

Exclusion

Exclusion Criteria:

  • Can not cooperate with the examination (including neuropsychological tests and scaleassessment);
  • There were memory disorders, dementia with lewy bodies and frontotemporal dementiabefore the onset of stroke events;
  • There were definite infectious diseases 2 weeks before admission; Have a seriousmental illness, previous history of cancer, alcohol or drug abuse;
  • Use of drugs that may affect cognitive function, including sedatives, anti-anxietydrugs, hypnotics, nootropic drugs, and cholinoid drugs;
  • Can not accept brain MRI examination

Study Design

Total Participants: 200
Treatment Group(s): 1
Primary Treatment: Pentoxifylline
Phase: 1/2
Study Start date:
April 10, 2024
Estimated Completion Date:
December 31, 2024

Study Description

Pentoxifylline can improve cognitive impairment after ischemic stroke, possibly by improving the level of cerebral blood flow, affecting the content of blood oxygen and metabolic substances in the brain, and then playing a protective role in the transmission of nerve electrical signals, and ultimately improving cognitive function.

Connect with a study center

  • BHan

    Shijiazhuang,
    China

    Active - Recruiting

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