Multiparametric SCores for Prediction of Myocardial FIbrosis in Patients with MITral VAlve PRolapse

Last updated: November 22, 2024
Sponsor: Centro Cardiologico Monzino
Overall Status: Active - Recruiting

Phase

N/A

Condition

Chest Pain

Heart Defect

Treatment

N/A

Clinical Study ID

NCT06341166
CCM1959
  • Ages > 18
  • All Genders

Study Summary

This is a multicenter, observational prospective and retrospective study which aims are:

  1. to compute a scoring model potentially predictive for the diagnosis of fibrosis by CMR in patients with MVP; 2) to identify specific features that may predispose to ≥ mild VAs or SCD in patients with MVP.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age ≥ 18 years

  • Echocardiographic diagnosis of mitral valve prolaspe, defined as a systolicdisplacement of one or both mitral leaflets ≥ 2 mm above the plane of the mitralvalve annulus in long-axis views

Exclusion

Exclusion Criteria:

  • age< 18 years

  • coexistence of other cardiomyopathies or other ≥ moderate valve diseases

  • scarce acoustic transthoracic echocardiographic window

  • usual contraindications for cardiac magnetic resonance

Study Design

Total Participants: 300
Study Start date:
June 19, 2023
Estimated Completion Date:
June 19, 2025

Study Description

Patients with mitral valve prolapse and non-significant mitral regurgitation generally have a good prognosis. A minority of patients with MVP suffers from ventricular arrhythmias. Different demographic, clinical, and electrocardiographic characteristics, as well as morphological and structural features of the MV were described as potential risk factors for ventricular arrhythmias, among which fibrosis of the left ventricular inferolateral wall and posterior papillary muscle as detected by cardiac magnetic resonance.

As cardiac magnetic resonance has some limitations, it is unknown if and which patients with mitral valve prolapse should undergo cardiac magnetic resonance in routine clinical practice, to search for late gadolinium enhancement as a surrogate for myocardial fibrosis.

Connect with a study center

  • Centro Cardiologico Monzino

    Milan, 20131
    Italy

    Active - Recruiting

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