The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU

Last updated: February 13, 2025
Sponsor: Peking University Third Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Kidney Failure

Kidney Disease

Renal Failure

Treatment

Renal microcirculation quantitatively assessed by Contrast-enhanced ultrasound

Clinical Study ID

NCT06341062
M2024078
  • Ages > 18
  • All Genders

Study Summary

The goal of this study is to quantitatively assess renal microcirculation changes by contrast-enhanced ultrasound and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore its predictive value in renal function recovery in patients with critical acute kidney injury. The main questions it aims to answer are:

  1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation.

  2. To explore the relationship between renal microcirculation and systemic hemodynamics.

  3. To explore the value of renal microflow changes quantitatively evaluated by contrast-enhanced ultrasound in predicting renal function recovery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age >18 years old;

  • AKI was diagnosed < 24 hours after first admission to intensive care unit (ICU) andthe expected length of stay in ICU ≥48 hours;

  • Meet Kidney Disease Improving Global Outcomes (KDIGO) 2012 diagnostic criteria foracute kidney injury;

  • Contrast-enhanced ultrasound was performed within 24 hours after diagnosis of acutekidney injury (AKI).

Exclusion

Exclusion Criteria:

  • Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysistreatment;

  • Kidney transplantation or renal malignancy;

  • Terminal stage of malignant tumor;

  • Pregnancy;

  • Renal artery stenosis or renal vein thrombosis;

  • Allergy to contrast agent SonoVue(BraccoSpA, Milan, Italy) or its components, or thepresence of severe cardiopulmonary insufficiency (e.g., right-to-left shunt heartdisease or pulmonary systolic blood pressure >90mmHg).

Study Design

Total Participants: 44
Treatment Group(s): 1
Primary Treatment: Renal microcirculation quantitatively assessed by Contrast-enhanced ultrasound
Phase:
Study Start date:
April 15, 2024
Estimated Completion Date:
June 30, 2026

Study Description

Quantitative analysis of cortical perfusion by contrast-enhanced ultrasound； Echocardiography； Quantitative results of renal artery and vein spectrum

Connect with a study center

  • Department of Ultrasound Diagnosis, Peking University Third Hospital

    Beijing, Beijing
    China

    Active - Recruiting

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