Wound Irrigation With Saline Versus Hypodilute-chlorhexidine After Cesarean Section (WISHES Study)

Last updated: June 3, 2025
Sponsor: Loma Linda University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Normal Saline

Irrisept

Clinical Study ID

NCT06339203
5240002
  • Ages > 18
  • Female

Study Summary

This investigator-initiated, open-label, randomized controlled trial will explore the effects of two treatment arms, comparing standard treatment with normal saline against Irrisept, a jet lavage solution containing a low concentration of Chlorhexidine Gluconate (CHG) at 0.05% in 99.95% sterile water for irrigation. The study aims to evaluate the impact on postoperative wound healing in patients who have undergone cesarean delivery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18 or older

  • Singleton pregnancy

  • Planned cesarean delivery at gestational age 37 weeks or later at Loma LindaUniversity Children's Hospital

  • Planned post-operative follow up with Loma Linda OBGYN

  • Speak English or Spanish

  • At least one of the following medical complications: Obesity BMI>= 30kg/m2,Diabetes, Spontaneous rupture of membranes, Intraamniotic infection

Exclusion

Exclusion Criteria:

  • Emergency cesarean delivery

Study Design

Total Participants: 400
Treatment Group(s): 2
Primary Treatment: Normal Saline
Phase:
Study Start date:
June 05, 2024
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Loma Linda University

    Loma Linda, California 92354
    United States

    Active - Recruiting

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