Sepsis is defined as a dysregulated host response to infection . Despite ongoing efforts,
both the incidence and mortality of sepsis have demonstrated limited reductions over the
past years,
There are several biomarkers that have already been studied for the early diagnosis of
sepsis. Some of these markers can be used in risk prediction and monitoring the outcome
of sepsis .
Triglyceride-glucose (TyG) index has emerged as a surrogate marker of insulin resistance
which is often prevalent in patients with sepsis. Red blood cell distribution width (RDW)
is a common clinical hematology indicator that reflects the heterogeneity of red blood
cell size. As a simple and inexpensive parameter, RDW has been successfully used to
predict the prognosis of many diseases, including cardiovascular disease, kidney disease,
diabetes mellitus, and liver disease .
Recent studies have also shown that RDW is significantly associated with the mortality of
sepsis. RDW to albumin ratio was evaluated as a novel and simple biomarker of
inflammation.
-C-reactive protein (CRP) is a sensitive indicator of the body, reflecting damage and
infection .
Serum albumin level drops significantly in the acute stage of infection (16). CRP/ALB
ratio (CAR) could be a marker to predict mortality in sepsis.
The neutrophil-lymphocyte ratio (NLR) is an-inflammatory biomarker that can be used as an
indicator of systemic inflammation. It is a simple that does not add costs to complete
blood count laboratory examinations, which are performed routinely in hospitals. It was
tested as a guide for the prognosis of various diseases, such as cancer, community
pneumonia and sepsis.
Although these various biomarkers that have been proposed, no single clinical or
biological indicator of sepsis has gained general acceptance . And to our knowledge, no
previous study compared between these indicators in prediction of sepsis outcome or
determined the clinical significance of combination of multiple biomarkers in prognosis
of sepsis .
