BEST-RPP Pilot: Screening for Esophageal Cancer in Rural Oregon Without an Endoscopy

Last updated: March 6, 2025
Sponsor: OHSU Knight Cancer Institute
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Esophageal Disorders

Digestive System Neoplasms

Esophageal Cancer

Treatment

Screening with swallowable esophageal cell-collection devices (SECD)

Clinical Study ID

NCT06335966
STUDY00025975
  • Ages > 50
  • Male

Study Summary

Recent advancements in swallowable esophageal cell-collection devices (SECD) offer a safe, minimally invasive, accurate, and low-cost alternative to esophageal screening without the need for an upper endoscopy. The BEST-RPP study aims to evaluate the acceptability and feasibility of using this novel approach to screen for Barrett's Esophagus (BE) and Esophageal Carcinoma (EAC) in rural primary care clinic settings in Oregon.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Signed informed consent

  • Willing and able to comply with the protocol

  • Live in a rural area

  • Chronic GERD Dx

  • 3 or more of the following risk factors: Male, age >50 years White race Tobaccosmoking Obesity Family history of BE or EAC in a first-degree relative

Exclusion

Exclusion Criteria:

Study Design

Total Participants: 110
Treatment Group(s): 1
Primary Treatment: Screening with swallowable esophageal cell-collection devices (SECD)
Phase:
Study Start date:
September 11, 2024
Estimated Completion Date:
January 30, 2026

Study Description

This is a proof-of-concept observational study to pilot the use of an FDA approved swallowable esophageal cell-collection device to screen for esophageal cancer in two rural primary care clinics in Oregon. The principal investigator will work with clinic staff to gauge the current use and understanding of SECDs as screening tools for esophageal cancer and to identify 50 patients at each site to approach about SECDs as an option for screening, for a total of 100 patients. If patients provide their consent and are eligible, they will undergo SECD administration for cancer screening in their primary care clinic. The study will evaluate the feasibility of use of this diagnostic tool in rural primary care settings, patient acceptability of screening for esophageal cancer via SECD in their primary care clinics, and where there are positive cases, the efficacy of diagnostic and treatment pathways to transitioning patients to tertiary centers for full diagnostic workup.

Connect with a study center

  • OHSU Knight Cancer Institute

    Portland, Oregon 97239
    United States

    Site Not Available

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