Polyphenols and Probiotics to Improve Menopausal Symptoms Via the Gut-Brain Axis

Inclusion Criteria:

• Adults >48 years

• Post-menopausal female subjects without clinical signs or symptoms of cardiovasculardisease, no menstruation cycle for more than 1 year, postmenopausal status conformedby female hormone analysis

• For intervention purposes, eligible participants are also required to have a mobilephone and be able to read and speak English.

Exclusion Criteria:

• • People with comorbid conditions that may limit participation in the study, such asa history of an acute cardiovascular event, uncontrolled hypertension, cancer ormajor psychiatric or cognitive problems

• People who are already participating in a weight loss programme

• People receiving drug treatment for lipid metabolisms (e.g., statins

• People with a history of long-term use of medicines known to influence glucosemetabolism (e.g., corticosteroids)

• People who take antibiotics or bacterial agents (Probiotics) within 1 month

• Pregnant women, women ready for pregnancy, and nursing mothers

• Post-menopausal female subjects without clinical signs or symptoms ofcardiovascular disease

• acute inflammation

• cardiac arrhythmia

• renal failure

• heart failure (NYHA II-IV)

• diabetes mellitus

• C-reactive protein > 0.5 mg/dL

• malignant disease

• hypotension (≤100 / 60 mm Hg)

• Women who require hormone replacement therapy during the development of theprotocol.