MIND Diet to Improve Cognitive Function in Mild Stroke Patients (MINDICOMS) II

Last updated: April 2, 2024
Sponsor: Zhejiang University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stroke

Dementia

Neurologic Disorders

Treatment

General dietary advice

Routine medical care

Localized MIND diet intervention

Clinical Study ID

NCT06331247
20230520-2
  • Ages 35-70
  • All Genders

Study Summary

A 6-month pilot randomized controlled trial designed to test the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet + usual medical care versus usual medical care on cognitive change and several other secondary outcomes through a randomized controlled trial in 60 mild stroke patients aged 35-70 years without dementia.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinically confirmed new cerebral infarction, onset hospitalization time ≤14 days
  • National Institutes of Health Stroke Scale (NIHSS) score of 0-6, with no difficulty inautonomous eating or aphasia
  • Baseline MMSE score being 16-25/30 points or MoCA score ≤24/30 points, with signs ofpost-stroke cognitive decline
  • Baseline MIND dietary pattern screening scale score ≤10/15 points
  • Body mass index no less than 18.0 kg/m2
  • Normal chewing function, able to eat hard foods such as nuts
  • Willing to participate and sign an informed consent form
  • Agree not to take over-the-counter nutritional supplements during the trial period
  • Able to understand research procedures and adhere to them throughout the entire studyperiod
  • Completed the run-in test

Exclusion

Exclusion Criteria:

  • Diagnosis of dementia at a county-level or above hospital before the stroke orsuspected to have pre-stroke dementia from the informant interview administered by aneurologist.
  • Participation in or have participated in other clinical trial studies within the pastyear
  • Allergies to foods involved in the experiment (nuts, berries, olive oil, or fish,etc.) or using drugs not compatible with foods involved.
  • Medication to treat Alzheimer's or Parkinson's disease
  • Diagnosis of cancer, severe liver and kidney disease, or current life expectancy lessthan 6 months
  • Diagnosis of depression, bipolar disorder, or other mental illnesses
  • Pregnancy or breastfeeding or with a pregnancy plan
  • Diagnosis of inflammatory bowel disease or other malabsorption-relatedgastrointestinal diseases
  • History of alcohol or drug abuse

Study Design

Total Participants: 60
Treatment Group(s): 3
Primary Treatment: General dietary advice
Phase:
Study Start date:
March 18, 2024
Estimated Completion Date:
December 31, 2025

Study Description

Mediterranean-DASH (Dietary Approach to Stop Hypertension) Intervention for Neurodegenerative Delay (MIND) Diet and Cognitive Decline in Mild Stroke Patients (MINDICOMS) II is a 6-month pilot randomized controlled trial designed to test the effects of the MIND diet on cognitive change and several other secondary outcomes among 60 individuals aged 35-70 years without dementia. The proposed MIND diet for this study is a hybrid of the Mediterranean and DASH diets but with selected modifications based on the most compelling evidence in the diet-dementia field and Chinese Dietary Guidelines 2022. Specifically, the proposed MIND diet will emphasize the consumption of whole grains, dark green leafy vegetables, dark red/yellow vegetables, other vegetables, berries and citrus, poultry, fish and seafood, beans and legume, nuts, olive and seed oils, and green tea, and restrict red and processed meats, animal fat, fried foods, and sweets and pastries. The trial will employ a parallel group design comparing the effects on global cognitive change of the MIND intervention diet to usual medical care among 60 mild stroke patients aged 35-70 years. Secondary outcomes will include cognitive function changes in several domains, brain imaging marker changes, dietary behaviour changes, daily living behaviour ability changes, mental health changes, and plasma biomarker changes. In addition, this trial will examine potential effect mediators and modifiers. The proposed study is sited at the Bo'Ao District, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou. Specialized laboratories will conduct biochemical analyses.

Connect with a study center

  • Second Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang 310058
    China

    Active - Recruiting

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