Comparing Efficiency of Mirogabalin and Pregabalin in Primary TKA

Last updated: April 5, 2025
Sponsor: Thammasat University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Knee Replacement

Osteoarthritis

Treatment

Pregabalin

Mirogabalin

Clinical Study ID

NCT06328062
TUH Mirogabalin TKA
  • Ages 50-85
  • All Genders

Study Summary

The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty.

The main question[s] it aims to answer are:

• Does mirogabalin have better pain reduction than pregabalin after unilateral primary total knee arthroplasty.

Participants will randomized to mirogabalin or pregabalin group and will take the drug for 6 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Age 50-85 years old

  2. Unilateral primary osteoarthritis undergoing primary TKA

  3. ASA I-III

Exclusion

Exclusion Criteria:

  1. GFR <60

  2. Allergy to drug in this study

  3. Cannot underwent spinal anesthesia and adductor canal block

  4. Taking gabapentinoid within 3 months before surgery

  5. History of previous knee surgery

  6. Severe liver disease

Study Design

Total Participants: 80
Treatment Group(s): 2
Primary Treatment: Pregabalin
Phase:
Study Start date:
April 01, 2024
Estimated Completion Date:
May 31, 2025

Study Description

After surgery is complete, you will be randomly assigned to receive painkillers Mirogabalin or Pregabalin along with other standard medications.

Surgery by Mirogabalin group: Participants received 5 mg of mirogabalin, taken as half a tablet, every day.

Twice a day, after breakfast and dinner, for 6 weeks. In the pregabalin group: Participants received 50 mg of pregabalin, one tablet taken daily.

Twice a day, after breakfast and dinner, for 6 weeks

Connect with a study center

  • Thammasat University Hospital

    Khlong Luang, Pathum Thani 12120
    Thailand

    Active - Recruiting

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