A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Help People With Excess Body Weight Lose Weight

Inclusion Criteria:

• Female of non-childbearing potential, or male. a. For US only: Female of childbearing potential using highly effective non-systemicmethods of contraception with low user-dependency at least 2 months prior toscreening and willingness to continue using it through-out the study, or male.

• Age 18-75 years (both inclusive) at the time of signing the informed consent.

• History of at least one self-reported unsuccessful dietary effort to lose bodyweight.

• a) BMI ≥ 27.0 kg/m2 with the presence of at least one weight-related co-morbidityincluding, but not limited to, hypertension, dyslipidaemia, obstructive sleep apnoeaor cardiovascular disease.

• b) BMI ≥ 30.0 kg/m2.

Exclusion Criteria:

• HbA1c greater than equal to 6.5% (48 millimoles per mole (mmol/mol)) as measured bythe central laboratory at screening.

• History of type 1 or type 2 diabetes mellitus.

• Treatment with any medication prescribed for the indication of obesity or weightmanagement within 90 days before screening.