Phase
Condition
Autism Spectrum Disorder (Asd)
Attention Deficit/hyperactivity Disorder (Adhd - Adults)
Williams Syndrome
Treatment
Sham repetitive TMS
Active repetitive TMS
Clinical Study ID
Ages 12-17 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
ADHD diagnosis
Ages 12-17 years
Stimulant use is allowed but must be discontinued 24 hours prior to and during daysof TMS visit
Exclusion
Exclusion Criteria:
Medical conditions contraindicated or associated with altered TMS risk profile,including history of intracranial pathology, epilepsy or seizure disorders,traumatic brain injury, brain tumor, stroke, intellectual disability, cerebralpalsy, neurodegenerative conditions, hearing impairment, metallic objects in thehead or any other serious medical condition
Presence of any implanted medical devices (e.g., ports, shunts, stimulators,cochlear implants)
For biological females who are post-menarche, current pregnancy based on urinepregnancy test.
Baseline problem of hearing impairment or chronic tinnitus
Any clinically significant finding on brain MRI
History of DSM-5 conduct disorder, major depressive disorder, bipolar disorder,obsessive compulsive disorder, anxiety disorder, psychotic disorder
Non-stimulant medication(s) for ADHD (e.g., alpha2 adrenergic agonist, atomoxetine,tricyclics)
Neuroleptic/antipsychotic medication(s)
Inability to undergo MRI
Active suicidality, history of suicidality, or high risk for suicide as assessed bya study physician
Substance abuse or dependence within the past year, based on 1) separate screeningprocess of asking parent/guardian and participant, and 2) positive urine drugscreen. Exception will be made for positive urine drug screen due to prescribed ADHDmedication
Study Design
Study Description
Connect with a study center
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229
United StatesActive - Recruiting
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