Hyperangulated vs Macintosh Blades for Intubation With Videolaryngoscopy in ICU

Last updated: May 16, 2024
Sponsor: Hospital Clinico Universitario de Santiago
Overall Status: Active - Recruiting

Phase

N/A

Condition

Respiratory Failure

Lung Injury

Acute Respiratory Distress Syndrome (Ards)

Treatment

Macintosh blade videolaryngoscope

Hyperangulated blade videolaryngoscope

Clinical Study ID

NCT06322719
INVIBLADE
  • Ages 18-90
  • All Genders

Study Summary

Tracheal intubation in the intensive care unit (ICU) is associated with high incidence of difficult intubation and complications. Videolaryngoscopes (VLs) devices have been proposed to improve airway management, and the use of VLs are recommended as first-line or after a first-attempt failure using direct laryngoscopy in ICU airway management algorithms. Although until relatively few years ago there were doubts about whether videolaryngoscopes had advantages over direct laryngoscopy for endotracheal intubation (ETI) in critically ill patients, two recent studies (DEVICE (1), INTUBATE (2)), and a Cochrane review (3) have confirmed that videolaryn should be used?, and what is the best blade? . There are two types of blades commonly used with videolaryngoscopes: the "Macintosh" blade with a slight curvature, and hyperangulated blades. The "Macintosh" blades have a lower angle of vision, but they have the advantage of being similar to the blades commonly used in direct laryngoscopy, making them easy to use for the person performing the ETI. Hyperangulated blades have a greater angle of vision, improving glottic visualization, especially in patients with an anterior glottis. However, the need to overcome this angulation could potentially hinder the passage of the endotracheal tube to the vocal cords. It is unknown if either blade has any advantage for intubating critically ill patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 18 years or older.

  • Admitted to an Intensive Care Unit.

  • Need for tracheal intubation during the stay in the ICU.

  • The device to be used for intubation is a videolaryngoscope

Exclusion

Exclusion Criteria:

  • Pregnancy or lactation.

  • Emergent tracheal intubation that does not allow for the randomization of theprocedure.

  • Need for tracheal intubation with a device other than the videolaryngoscope (fiberoptic bronchoscope, direct laryngoscopy, tracheostomy, etc.).

  • Tracheal intubation performed outside the ICU (Emergency Department, Hospital ward,etc.).

Study Design

Total Participants: 1036
Treatment Group(s): 2
Primary Treatment: Macintosh blade videolaryngoscope
Phase:
Study Start date:
May 01, 2024
Estimated Completion Date:
May 30, 2025

Study Description

The purpose of this prospective multicenter randomized study is to compare successful intubation on the first attempt with the Macintosh videolaryngoscope vs the hyperangulated videolaryngoscope during tracheal intubation in ICU patients.The hypothesis of the study is that tracheal intubation using the hyperangulated videolaryngoscope will improve the frequency of successful intubation on the first attempt in ICU patients requiring intubation in the intensive care unit.

Connect with a study center

  • University Clinical Hospital of Santiago de Compostela

    Santiago de Compostela, A Coruña 15866
    Spain

    Active - Recruiting

  • Complexo Hospitalario Universitario de A Coruña

    A Coruña,
    Spain

    Active - Recruiting

  • Hospital General de Albacete

    Albacete,
    Spain

    Site Not Available

  • Hospital de la Santa Creu i Sant Pau, Barcelona

    Barcelona,
    Spain

    Site Not Available

  • Hospital Universitario de Cáceres

    Cáceres,
    Spain

    Site Not Available

  • Hospital de Denia

    Denia,
    Spain

    Site Not Available

  • Hospital General Universitario de Eche

    Elche,
    Spain

    Site Not Available

  • Hospital Universitario de Cabueñes, Gijón

    Gijón,
    Spain

    Site Not Available

  • Hospital Virgen de las Nieves, Granada

    Granada,
    Spain

    Site Not Available

  • Hospital Universitario de Gran Canaria Doctor Negrín

    Las Palmas De Gran Canaria,
    Spain

    Site Not Available

  • Complejo Asistencial Universitario de León

    León,
    Spain

    Site Not Available

  • Hospital Universitario Lucus Augusti, Lugo

    Lugo,
    Spain

    Active - Recruiting

  • Hospital Gregorio Marañón, Madrid

    Madrid,
    Spain

    Site Not Available

  • Hospital Universitario 12 de Octubre, Madrid

    Madrid,
    Spain

    Site Not Available

  • Hospital Universitario La Paz, Madrid

    Madrid,
    Spain

    Active - Recruiting

  • Hospital Universitario La Princesa

    Madrid,
    Spain

    Site Not Available

  • Hospital Universitario Puerta de Hierro, Majadahonda

    Majadahonda,
    Spain

    Site Not Available

  • Hospital Universitario de Móstoles

    Móstoles,
    Spain

    Site Not Available

  • Complexo Hospitalario Universitario de Ourense

    Ourense,
    Spain

    Site Not Available

  • Hospital Universitario Central de Asturias (HUCA), Oviedo

    Oviedo,
    Spain

    Site Not Available

  • Clínica Universidad de Navarra, Pamplona

    Pamplona,
    Spain

    Site Not Available

  • Complexo Hospitalario Universitario de Pontevedra

    Pontevedra,
    Spain

    Site Not Available

  • Hospital Universitario Donostia, San Sebastián

    San Sebastián,
    Spain

    Active - Recruiting

  • Hospital Universitario Marqués de Valdecilla, Santander

    Santander,
    Spain

    Site Not Available

  • Complejo Asistencial de Segovia

    Segovia,
    Spain

    Site Not Available

  • Hospital Clínico Universitario de Valencia

    Valencia,
    Spain

    Site Not Available

  • Hospital Universitario La Fe de Valencia

    Valencia,
    Spain

    Site Not Available

  • Complexo Hospitalario Universitario Álvaro Cunqueiro de Vigo

    Vigo,
    Spain

    Site Not Available

  • Hospital Ribera Povisa Vigo

    Vigo,
    Spain

    Active - Recruiting

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