Clemastine Fumarate in the Treatment of Neurodevelopmental Delays in Williams Syndrome

Inclusion Criteria:

1. Age 3-12 years old;

2. Positive fluorescence in situ hybridization (FISH) test confirmed Williams syndrome;

3. GTF2I gene mutation was detected by whole exon;

4. Heart safety variables are normal (e.g. normal ECG, blood pressure 120-129/80-84)

Exclusion Criteria:

1. WS patients with other gene mutations;

2. Used antihistamines, monoamine oxidase inhibitors, barbiturates and sedatives, aswell as drugs affecting cognitive behavior, limb movement, white matter myelin, andMRI within 2 months before enrollment;

3. Patients with narrow-angle glaucoma, narrow peptic ulcer, pyloroduodenalobstruction, symptomatic prostatic hypertrophy and bladder neck obstruction;Accompanied by severe immunodeficiency disease;

4. Allergic to Clomastine fumarate or other arylalkylamine antihistamines or anyreceptor;

5. According to the recent interpretation of MRI and neuroradiology experts or WS,there are obvious brain lesions that are not related to WS disease;

6. Clinically significant metabolic, hematological, liver, immune, urinary, endocrine,neurological, pulmonary, psychiatric, skin, allergic, renal, or other major diseasesthat may affect the interpretation of study findings or patient safety in WS'sjudgment;