Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)

Last updated: May 14, 2025
Sponsor: Seattle Children's Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Ulcerative Colitis

Irritable Bowel Syndrome (Ibs)

Esophageal Disorders

Treatment

Colonoscopy w/ biopsy

Esophagogastroduodenoscopy (EGD) with biopsy

Clinical Study ID

NCT06315179
STUDY00004616
  • Ages 6-21
  • All Genders

Study Summary

This is a prospective observational study collecting long-term clinical data and samples for research in pediatric inflammatory bowel disease (IBD) patients with gut inflammation and a control cohort of pediatric patients with disorders of the brain-gut interactions (DBGI) with no detectable gut inflammation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Suspected diagnosis of CD (Crohn's Disease), UC (Ulcerative Colitis) orIndeterminate colitis (IC)

Exclusion

Exclusion Criteria:

  • Evidence of Other Complicating Medical Issues:

  • Other serious medical conditions, such as neurological, liver, kidney, or systemicdisease

  • Pregnancy

  • Tobacco, alcohol, or illicit drug abuse

Study Design

Total Participants: 200
Treatment Group(s): 2
Primary Treatment: Colonoscopy w/ biopsy
Phase:
Study Start date:
May 10, 2024
Estimated Completion Date:
January 31, 2030

Study Description

Research procedures will coincide with clinical visits at institutional standards. As part of their clinical disease evaluation, participants will have blood, stool, and tissue collected as indicated by their disease course. Additional research samples or data will be collected during these visits. Participants will be asked to collect urine samples specifically for research.

Connect with a study center

  • Seattle Children's Hospital

    Seattle, Washington 98105
    United States

    Active - Recruiting

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