Buprenorphine for Individuals in Jail

Inclusion Criteria:

• Adult male or female inmates at participating jail who are eligible for releasewithin 120 days (sentenced and/or pretrial [note: individuals who might be sentencedto state/federal prison will be excluded]); Those individuals who are pre-trialand/or sentenced who are completing their sentence in the community (probation,parole, home detention, electronic monitoring, drug or other treatment court [orequivalent]) will be eligible to participate;

• History of opioid use disorder (meeting DSM-5 criteria of moderate or severe opioiduse disorder at the time of incarceration; individuals not meeting theopioid-disorder criterion will be eligible if they were treated in an opioid agonisttreatment program during the year before incarceration);

• Suitability for XR-B and/or SL-B treatment as determined by medical evaluation;

• Willingness to enroll in XR-B or SL-B treatment in jail and continue in thecommunity;

• Planning to live in Baltimore City or the Baltimore Region;

Exclusion Criteria:

• Liver function test levels greater than 5 times normal (if we are unable to obtainlabs, a determination by the study physician will be made to allow inclusion);

• Active medical illness that may make participation hazardous (e.g., unstablediabetes, heart disease; moderate to severe renal impairment; adequately treatedmedical conditions are acceptable);

• Conditions or medications that may predispose to QTc prolongation (personal orfamily history of long QT syndrome, hypokalemia, medications that prolong QTcinterval, e.g., macrolide antibiotics, azole antifungal compounds, anti-arrythmics,antipsychotics and antidepressant);

• Untreated psychiatric disorder that may make participation hazardous (e.g.,untreated psychosis, bipolar disorder with mania; adequately treated psychiatricdisorders and appropriate psychotropic medications will be allowed);

• History of allergic reaction to buprenorphine;

• Suicidal ideation (within the past 6 months);

• Inability to pass a study enrollment quiz; and

• Currently receiving non-buprenorphine MOUD in jail (methadone, naltrexone).