Open Versus Laparoscopic Ablation of Liver Malignancies

Last updated: March 11, 2024
Sponsor: Rigshospitalet, Denmark
Overall Status: Active - Recruiting

Phase

N/A

Condition

Abdominal Cancer

Liver Cancer

Digestive System Neoplasms

Treatment

Open ablation

Laparoscopic ablation

Clinical Study ID

NCT06304766
H-23015954
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to compare laparoscopic ablation to open ablation of liver malignancies regarding complication rates and ablation response as well as quality of life following the surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • One or more tumors not amenable to percutaneous ablation, age ≥ 18, signed informedconsent, diagnosis of primary liver cancer or liver metastases from any primary tumor,and tumor suitable for ablation as primary treatment.

Exclusion

Exclusion Criteria:

  • Ablation performed in conjunction with resection, patients who cannot cooperate withthe study, and patients who do not understand or speak Danish.

Study Design

Total Participants: 80
Treatment Group(s): 2
Primary Treatment: Open ablation
Phase:
Study Start date:
December 15, 2023
Estimated Completion Date:
December 31, 2025

Study Description

Liver malignancies is a major cause of cancer-related mortality and the incidence is increasing. Patients with liver malignancies are often left with limited surgical treatment options due to extensive tumor burden or comorbidities. Ablation is a less invasive treatment for these patients that can be performed percutaneously, by laparoscopy or open surgery. Ablation during open surgery has a high potential of complications. Laparoscopic ablation presumably has a lower complication rate than during open surgery, yet still offers some of the same advantages needed for tumors in locations not favorable for percutaneous ablation. This study aims to compare laparoscopic ablation with ablation during open surgery to investigate a treatment option with a supposed lower complication rate and equally treatment effectiveness after one month.

Connect with a study center

  • Rigshospitalet

    Copenhagen, 2100
    Denmark

    Active - Recruiting

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