Phase
Condition
Healthy Volunteers
Treatment
ABBV-932
Clinical Study ID
Ages 23-55 All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Body Mass Index (BMI) is >= 18.0 to <= 35.0 kg/m2.
Supine pulse rate >= 50 bpm and <= 100 bpm obtained after a 5-minute rest atScreening.
Supine systolic blood pressure (SBP) <= 160 mm Hg and >= 90 mm Hg and supinediastolic blood pressure (DBP) <= 90 mm Hg and obtained after a 5-minute rest atScreening.
Exclusion
Exclusion Criteria:
Orthostatic (SBP decrease of >= 30 mmHg, DBP decrease of >= 20 mmHg, or pulseincrease of >= 30 bpm) as determined after standing for 5 minutes.
Current or history of suicidal ideation as indicated by answering "Yes" answer toSuicidal Ideation Questions #4 or #5 on the Columbia-Suicide Severity Rating Scale (C-SSRS) at Screening in the past 3 months or any "Yes" answer to Suicidal BehaviorQuestions #1-5 in the past year. Non-suicidal self-injurious behavior is notexclusionary.
History of suicide attempt(s) within 1 year prior to study drug administration asevidenced by answering "Yes" to any Suicidal Behavior Questions (a "Yes" toNon-Suicidal Self-Injurious Behavior is not exclusionary).
Contraindications to MRIs (metal implants, paramagnetic objects contained within thebody, claustrophobia, etc.)
Clinically significant findings as determined from screening brain MRI.
History of previous radiation exposure for research purposes such that participationin this study will result in cumulative ionizing radiation exposure >10 mSv in thepast 12 months, in additional to normal background exposure.
Study Design
Connect with a study center
Parexel Early Phase Clinical Unit /ID# 264286
Harrow, HA1 3UJ
United KingdomSite Not Available
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