A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)

Key Inclusion Criteria:

1. PICC is clinically indicated for at least 14 days and is anticipated to remain inplace for at least 14 days

2. Eastern Cooperative Oncology Group (ECOG) Performance Status ≤2 or equivalentfunctional status as described in the protocol

3. Body weight ≥45 kg and ≤130 kg during the screening period

4. International normalized ratio (INR) and aPTT values at or below the upper limit ofnormal as defined by the local lab during the screening period

5. Platelet count ≥100 x 10^9/L during the screening period as described in theprotocol

Key Exclusion Criteria:

1. Unsuccessful PICC placement or any other complication associated with this procedurethat in the opinion of the study investigator may present any safety concerns to theparticipant

2. History of prior venous thrombosis in the arm in which the PICC is to be placed

3. Peripheral catheter(s) in the same arm in which the PICC is to be placed or expectedneed for peripheral catheter(s) placement in the same arm the PICC is to be placedas described in the protocol

4. History of known thromboembolic disease or thrombophilia

5. Participants requiring therapeutic anticoagulation and/or antiplatelet therapy asdescribed in the protocol

6. Expected to receive cancer therapy or other medication associated with a priorepisode of Grade 4 thrombocytopenia as described in the protocol

7. Any history of intracranial or intraocular bleeding, excessive operative orpost-operative bleeding, traumatic spinal or epidural anesthesia, or history ofbleeding diathesis (such as but not limited to Hemophilia A or B, von Willebrand'sdisease, fibrinogen deficiency, and other inherited or acquired bleeding disorders)as described in the protocol

Note: Other protocol defined inclusion/exclusion criteria apply