Bowel Preparation for Colonoscopy Among Individuals With Crohn's and Ulcerative Colitis Disease.

Last updated: January 6, 2025
Sponsor: University of Manitoba
Overall Status: Active - Recruiting

Phase

4

Condition

Inflammatory Bowel Disease

Ulcerative Colitis

Ulcers

Treatment

KleanLyte

Bi-PegLyte

Clinical Study ID

NCT06298461
BowelPrep
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to compare how effective and how tolerable two different bowel preparation laxatives are for colonoscopy. The aim is to compare oral sulfate solution (OSS) to another laxative called 2L polyethylene glycol (PEG) solution to see which is more effective and more tolerable by individuals with IBD (Crohn's disease or Ulcerative colitis).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Crohn's disease or ulcerative colitis patients scheduled or about to be scheduledfor colonoscopy.

  2. Age > 18 years

  3. Out-patients

Exclusion

Exclusion Criteria:

  1. Prior subtotal or total colorectal resection

  2. Contraindications to use of 2L polyethylene glycol (2L-PEG) or Oral Sulfate Solution (OSS): Known renal insufficiency, congestive heart failure, cirrhosis, severeelectrolyte imbalance.

  3. Colonoscopy being repeated because of poor preparation in the preceding six months.

  4. Allergies to the employed bowel preparations

  5. Toxic megacolon, ileus, suspected or diagnosed bowel obstruction.

  6. IBD patients thought to be too sick to undergo a full colonoscopy preparation in theopinion of the investigator/treating physician; hospitalized crohn's disease orulcerative colitis patients.

  7. Pregnancy

Study Design

Total Participants: 418
Treatment Group(s): 2
Primary Treatment: KleanLyte
Phase: 4
Study Start date:
July 04, 2024
Estimated Completion Date:
May 31, 2026

Connect with a study center

  • University of Manitoba

    Winnipeg, Manitoba H2X 1R9
    Canada

    Active - Recruiting

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