Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy

Phase

N/A

Condition

Kidney Failure (Pediatric)

Kidney Failure

Focal Segmental Glomerulosclerosis

Treatment

Erector spinae plane block

Postoperative analgesia management with Paracerol® and IV PCA with Talinat®

Quadratus lumborum plane block

Clinical Study ID

NCT06298227

Medipol Hospital 1

Ages 18-65
All Genders

Study Summary

Ultrasound (US) guided Quadratus Lumborum Block (QLB) is performed at the level of the 12th rib, in the parasagittal oblique plane, at the L1-L2 level. As there are modifications of the block generally local anesthetic is given between quadratus lumborum (QL) and psoas major (PM) muscles (Anterior QLB). The QLB provides a sensory block between T7 - L1. Therefore, QLBs are used to provide postoperative analgesia for abdominal, obstetric, gynecologic, and urologic surgeries.

US-guided erector spinae plane block (ESPB) is performed at the level of the T11 transverse process. After visualization of the erector spinae (ES) muscle and the transverse process, local anesthetic is injected under the ES muscle. ESPB provides a sensory block of the anterior, posterior, and lateral thoracic and abdominal walls accordingly it's used for postoperative analgesia after thoracal wall repairs, thoracotomies, percutaneous nephrolithotomies, nephrectomies, and ventral hernia repairs.

This study aims to compare the effectiveness of US-guided ESPB and QLB on postoperative pain control after laparoscopic nephrectomy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

American Society of Anesthesiologists (ASA) classification I-II
Scheduled for living donor laparoscopic nephrectomy under general anesthesia

Exclusion

Exclusion Criteria:

history of bleeding diathesis,
receiving anticoagulant treatment,
known local anesthetics and opioid allergy,
infection of the skin at the site of the needle puncture,
pregnancy or lactation,
patients who refuse the procedure or participation in the study

Study Design

Erector spinae plane block

March 11, 2024

April 30, 2025

Study Description

Nephrectomy for renal transplantation is a commonly performed procedure. The laparoscopic live donor nephrectomy (LLDN) is associated with many benefits and has become the gold standard for kidney retrieval surgery. As compared to open donor nephrectomy (ODN), LLDN has been shown to have less post-operative pain, shorter hospital stays, and faster recovery. Even though LLDN is less traumatic, some patients undergoing laparoscopic live donor nephrectomy still suffer significant postoperative pain require parenteral opioids, and have a risk for chronic pain.

The postoperative pain mechanism of LLDN is multifactorial - port pain, pain caused by incisions to retrieve the kidney, pelvic organ nociception, diaphragmatic irritation, and discomfort of a urinary catheter. Opioids, epidural anesthesia, Transversus Abdominal Plane (TAP) Block, and local infiltration of local anesthetics are used to prevent postoperative pain after LLDN.

In this study, the investigators aim to compare the effectiveness of US-guided ESPB and QLB on postoperative pain control after laparoscopic nephrectomy.

Connect with a study center

Istanbul Medipol University Mega Hospital Complex
Istanbul, Bağcılar
Turkey
Active - Recruiting

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