eTMS for Veterans and First Responders With PTSD

Last updated: July 19, 2024
Sponsor: Virginia Polytechnic Institute and State University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Post-traumatic Stress Disorders

Treatment

Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)

Clinical Study ID

NCT06294106
24-212
  • Ages 18-65
  • All Genders

Study Summary

A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Veteran or first responder

  • diagnosed with post-traumatic stress disorder with PCL-5 cutoff of 31 or above

Exclusion

Exclusion Criteria:

  • Claustrophobia

  • Contraindications to MRI

  • Pregnant

  • Uncontrolled medical, psychological, or neurological conditions

  • Unable to calculate EEG alpha frequency

  • History of ECT or rTMS

  • History of intracranial lesion or increased intracranial pressure

  • History of stroke

  • History of other neurologic conditions

  • Family history of epilepsy

  • Personal history of epilepsy

  • certain medications

Study Design

Total Participants: 20
Treatment Group(s): 1
Primary Treatment: Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)
Phase:
Study Start date:
June 10, 2024
Estimated Completion Date:
April 30, 2026

Study Description

Veterans and first responders diagnosed with PTSD will be studied to evaluate safety and efficacy of an EEG personalized TMS paradigm. All participants will undergo 2 days of extensive testing prior to eTMS application and 2 days of testing after. Testing will include MRI, OPM, EEG, behavioral tasks, questionnaires, and an EEG sleep study.

Connect with a study center

  • Fralin Biomedical Research Institute

    Roanoke, Virginia 24016
    United States

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.