Microwave Ablation With Splenic Artery Occlusion for Secondary Hypersplenism

Last updated: March 3, 2024
Sponsor: Tianjin Medical University Cancer Institute and Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neoplasm Metastasis

Treatment

microwave ablation of the spleen

Splenic artery balloon implantation

Clinical Study ID

NCT06292715
Microwave Ablation01
  • Ages 18-65
  • All Genders

Study Summary

This study assesses the effectiveness of microwave ablation of the spleen in conjunction with splenic artery occlusion for treating secondary hypersplenism.

Eligibility Criteria

Inclusion

Inclusion Criteria:

    1. written informed consent signed prior to enrolment 2. age > 18 years, both sexes 3.Patients with severe hypersplenism secondary to cirrhosis with clinical diagnosis,White blood cells <3×109/L, and/or platelet <50×109/L 4.Patients who have beenrepeatedly given drugs to raise white blood cells and platelets in clinical practicehave poor effect 5.Mental problems such as clinical symptoms or anxiety in patientsrequire interventional treatment for hypersplenism

Exclusion

Exclusion Criteria:

  • Patients with any of the following are not eligible for enrollment in this study
  1. Coagulopathy or other blood disorders
  2. Recent use of anticoagulant drugs
  3. Severe hypertension and cardiac insufficiency
  4. Bone marrow aspiration results showed bone marrow suppression
  5. Combined with other spleen malignant diseases
  6. Severe skin infection at the puncture site
  7. Participated in other clinical studies within 2 months prior to the start of thestudy
  8. Patient or his/her authorized person is unwilling to sign a written informedconsent form or unwilling to comply with the study protocol

Study Design

Total Participants: 35
Treatment Group(s): 2
Primary Treatment: microwave ablation of the spleen
Phase:
Study Start date:
January 20, 2024
Estimated Completion Date:
December 31, 2026

Study Description

This open-label, single-arm, single-center clinical trial investigates the combined approach of microwave ablation of the spleen and splenic artery occlusion for managing secondary hypersplenism.

Connect with a study center

  • Tianjin Medical University Cancer Institute & Hospital

    Tianjin, Tianjin 300060
    China

    Active - Recruiting

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