Red Light Ptosis Proof-of-Concept

Last updated: February 27, 2024
Sponsor: University College, London
Overall Status: Active - Recruiting

Phase

N/A

Condition

Mitochondrial Diseases

Treatment

Near-infrared light

Clinical Study ID

NCT06292182
160802
332942
58964
  • Ages 3-18
  • All Genders

Study Summary

This study tests a new treatment to help with droopy eyelids (ptosis) and eye movement problems (squint) in children and young people with genetically confirmed mitochondrial conditions - using red-light.

We use a torch to shine a red light through the closed eyelid for 3 minutes a day. The study will run for 18 months.

We believe that this treatment could help strengthen the muscle in the eyelid to make it easier to open the eyes, and could also help some children with squint.

Eligibility Criteria

Inclusion

Inclusion: Age 3 to less than 18 years Genetically confirmed diagnosis of primary mitochondrial disease (known pathogenic mutation(s) in mitochondrial or nuclear DNA known to cause primary mitochondrial disease) Ptosis

Exclusion: Genetic diagnosis not consistent with primary mitochondrial disease. No genetic diagnosis Unable to cooperate with light treatment or ophthalmological assessments.

Study Design

Total Participants: 10
Treatment Group(s): 1
Primary Treatment: Near-infrared light
Phase:
Study Start date:
February 08, 2024
Estimated Completion Date:
November 30, 2025

Connect with a study center

  • Moorfields Eye Hospital NHS Foundation Trust

    London, EC1V 2PD
    United Kingdom

    Active - Recruiting

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