Efficacy and Safety of AJU-S56 5% in Dry Eye Syndrome Patients

Inclusion Criteria:

• Male and Female who over 19 years old
• Moderate to Severe Dry Eye Disease Patients
• Must meet all criteria listed below at least in one eye or both eyes.

1. TCSS (National eye institute (NEI) scale)≥ 4
2. Ocular discomfort score (ODS) ≥ 3
3. Schirmer test(without anesthesia) ≤ 10mm in 5 mins
4. Tear break-up time ≤ 6 secs

• Written informed consent to participate in the trial

Exclusion Criteria:

• Those who have clinically significant eye disease not related to dry eye syndrome
• Those who have worn contact lenses before 1week Screening visit or have to wearcontact lenses or need to wear contact lenses during study period
• Those who have medical history with intraocular surgery 12months before screeningvisit
• Use of corticosteroid, beta blocker and anticholinergic agent within 4 weeks
• Participation in other studies within 4weeks of screening visit