Probiotics for Gallstones in Post-bariatric Surgery Patients

Last updated: February 29, 2024
Sponsor: Shandong Linglong Yingcheng Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Liver Disorders

Gall Bladder Disorders

Treatment

Bifidobacterium group

Ursodoxycholic acid group

Clinical Study ID

NCT06287931
sdllycyy001
  • Ages 20-60
  • All Genders

Study Summary

Obesity is an increasing epidemic worldwide and has a significant impact on human health and socioeconomics. Multiple studies have shown that bariatric surgery increases the risk of postoperative gallbladder stones. Contributing factors to gallstone formation include gallbladder motility and bile supersaturation due to rapid weight loss and cholesterol mobilization. At present, the prevention and treatment of gallbladder stones in obese patients after bariatric surgery are still controversial. In recent years, the study of ursodeoxycholic acid in preventing gallbladder stone formation after bariatric surgery has become a research hotspot. At the same time, other studies have shown that taking probiotics or digestive enzymes may improve gastrointestinal symptoms and improve quality of life after bariatric surgery. Therefore, the purpose of this study was to determine the ability of probiotics to prevent gallstone formation after bariatric surgery and to evaluate the impact of oral probiotics on quality of life in patients after bariatric surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients receiving bariatric surgery for morbid obesity
  • Patiets at ages between 20 to 60 y/o
  • Patients willing to follow up regulary after bariatric surgery

Exclusion

Exclusion Criteria:

  • Patients having gallstones before bariatric surgery
  • Patients refusing taking probiotics or refusing regular follow up after bariatricsurgery

Study Design

Total Participants: 400
Treatment Group(s): 2
Primary Treatment: Bifidobacterium group
Phase:
Study Start date:
January 01, 2024
Estimated Completion Date:
June 01, 2025

Connect with a study center

  • Shandong Linglong Yingcheng Hospital

    Yantai, Shandong 264000
    China

    Active - Recruiting

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