Palmaris Longus Muscle and Dupuytren

Last updated: April 10, 2025
Sponsor: Universitaire Ziekenhuizen KU Leuven
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dupuytren's Disease

Treatment

Non-invasive tests to determine the presence or absence of the palmaris longus tendon in both hands.

Ultrasound

Clinical Study ID

NCT06281509
S68374
  • Ages > 50
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Dupuytren disease is a medical condition characterized by the painless formation of nodules in the palm of the hand. Cords are formed on the palmar fascia, a connective tissue sheet in the palm of the hand. This fascia is seen as the vestigial remnant of the palmaris longus tendon. The PLM attaches to the fascia palmaris. A muscle that not everyone has and can therefore be clearly missed. This raises the question of whether the presence of the musculus palmaris longus has any association with the development, recurrence and/or progression of DD and contractures. To investigate a potential predisposition, this study intend to assess the prevalence of the PLM in a group of individuals affected by DD and compare it with a control group (age matched, no signs of DD) without the condition.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • The participant or his/her legally authorized representative voluntary signed theinformed consent prior to the first assessment.

  • 50 years of age or higher.

  • Has Dupuytren disease (primary or recurrent). (Only applicable for participants ofDD group)

  • Has no medical conditions affecting the function of the hand (musculoskeletalpathology, vascular or neurological conditions such as CRPS, rheumatoid arthritisand paralysis). (Only applicable for participants of control group)

Exclusion

Exclusion Criteria:

  • Patients < 50 years

  • Patients with cognitive impairments.

  • Patients showing signs of medical conditions affecting the function of the hand (musculoskeletal pathology, vascular or neurological conditions such as CRPS,rheumatoid arthritis and paralysis). (Only applicable for participants of controlgroup)

Study Design

Total Participants: 240
Treatment Group(s): 2
Primary Treatment: Non-invasive tests to determine the presence or absence of the palmaris longus tendon in both hands.
Phase:
Study Start date:
February 16, 2024
Estimated Completion Date:
June 01, 2025

Study Description

Dupuytren disease is also known as Dupuytren contracture. It is a medical condition characterized by the painless formation of nodules in the palm of the hand. As the disease progresses, approximately 21% - 50% of all patients experience a transformation of these nodules (stage 0/N of Tubiana) into cord-like structures. These cords, in turn, lead to finger contractures (Tubiana stages 1-4) with impairment of hand mobility and stiffening of the palmar skin. The cords are formed on the palmar fascia, a connective tissue sheet in the palm of the hand. This fascia is seen as the vestigial remnant of the palmaris longus tendon. The PLM attaches to the fascia palmaris. A muscle that not everyone has and can therefore be clearly missed. This raises the question of whether the presence of the musculus palmaris longus has any association with the development, recurrence and/or progression of DD and contractures. To investigate a potential predisposition, this study intend to assess the prevalence of the PLM in a group of individuals affected by DD and compare it with a control group (age matched, no signs of DD) without the condition. Interestingly, prior research has already explored this topic. Despite the publication dating back to 1986, it reported a significantly higher occurrence of the palmaris longus tendon in patients affected by DD. Furthermore, a second article from the same year concluded a significant decrease in recurrence when the palmaris longus tendon was resected in combination with regional fasciectomy. Remarkably, no other research on this topic was found despite the promising results of both articles.

Connect with a study center

  • Universitaire Ziekenhuizen KU Leuven

    Leuven, Vlaams-Brabant 3000
    Belgium

    Active - Recruiting

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