Observation of Environment and Reproductive-Endocrine Effects

• INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Male or female, referring to sex assigned at birth (cis gender)

2. Age > 8 years and weight >= 12 kg

3. A diagnosis of hypogonadism, infertility or other reproductive dysfunction Some specific diagnoses (as defined in standard guidelines) will include:

• Male or female hypogonadism

• Obesity/metabolic syndrome related to hypogonadism.

• Other reproductive dysfunction (e.g., secondary to endocrine dysfunction,thyroid disorders, Cushing syndrome, pharmacotherapy, etc.)

• Premature Ovarian Insufficiency

• Isolated hypogonadotropic hypogonadism

• Polycystic Ovarian Syndrome

• Delayed Puberty

• Precocious puberty

• Perimenopause and post-menopausal states

• Androgen Excess States (Nonclassic Congenital Adrenal Hyperplasia, Extremehyperinsulism, Idiopathic etc.) or

-Exhibiting signs of a diagnosis of hypogonadism, e.g., Bosma arrhiniamicrophthalmia syndrome (BAMS)

4. Ability of participant, legal guardian, or Legally Authorized Representative (LAR)to understand and the willingness to sign a written informed consent document.

EXCLUSION CRITERIA:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. A diagnosis of a serious medical disorder such as malignancy or heart disease willbe grounds for exclusion at the discretion of the PI or AI.

2. Inability to follow up with the research study and/or perform study procedures, atthe discretion of the PI or AI.

3. Pregnant participants, less than 18 years of age, for their safety, since there isnot a trained doctor on the study to give proper medical care to pregnantindividuals less than 18 years of age.

Individuals who do not meet the criteria for participation in this study (screen failure) because of an acute, reversible or transient medical reason may be rescreened upon reversal, improvement or stabilization of their clinical status. Participants who develop an acute, reversible or transient medical condition during the study may return upon reversal, improvement or stabilization of their clinical status.