A Study of RGT001-075 in Participants With Obesity or Overweight With Weight-Related Comorbidities

Inclusion Criteria:

• Age ≥ 18 and ≤ 75 years

• Have a BMI ≥27 kg/m² and ≤ 45 kg/m²

• Have had a stable body weight for the 3 months prior to randomization

Exclusion Criteria:

• Have obesity induced by other endocrinologic disorders or diagnosed monogenetic orsyndromic forms of obesity

• Have a prior or planned surgical treatment for obesity

• Have or plan to have endoscopic and/or device-based therapy for obesity

• Have any prior diagnosis of diabetes

• Have an electrocardiogram (ECG) with abnormalities

• Have a history of Major Depressive Disorder (MDD) or other severe psychiatricdisorders within the last 2 years

• Have a history of suicide attempt.