Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery

Last updated: May 5, 2025
Sponsor: University Tunis El Manar
Overall Status: Active - Recruiting

Phase

N/A

Condition

Inflammation

Treatment

Lidocaine IV

Ketamine Injectable Solution

Clinical Study ID

NCT06272461
UTEM ELKI
  • Ages 18-90
  • All Genders

Study Summary

Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).

For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours.

For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours.

Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.

Eligibility Criteria

Inclusion

INCLUSION CRITERIA:

  • Patients aged 18 or older.

  • American society of anesthesiologists' (ASA) physical status of I-III.

  • Elective open colorectal surgery.

NON INCLUSION CRITERIA:

  • Patients with contraindications to lidocaine or ketamine.

  • Corticosteroid therapy within the last 6 months.

  • History of immunosuppressive therapy.

  • History of surgery in the last 3 months.

  • Personal medical history of inflammatory bowel disease.

  • Personal medical history of cardiac arrythmias or conduction disorders.

  • Alcohol or drug abuse.

  • Chronic use of opioids or benzodiazepines.

Exclusion

EXCLUSION CRITERIA:

  • Severe intraoperative complications.

  • Duration of surgery longer than 5 hours.

Study Design

Total Participants: 50
Treatment Group(s): 2
Primary Treatment: Lidocaine IV
Phase:
Study Start date:
October 01, 2023
Estimated Completion Date:
July 30, 2025

Study Description

Patients undergoing open colorectal surgery with tumor resection were randomised prospectively into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).

For the IV-Lido group (n=25), patients received a loading dose of 1.5 mg/kg of Lidocaine than a continuous infusion of 1.5 mg/kg/h over twenty-four hours.

For the IV-Keta goup(n=25), patients received a loading dose of 0.15mg/kg of Ketamine than a continuous injection of 0.15 mg/kg/h of Ketamine over twenty-four hours.

For both groups, plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively. Plasma IL-6 concentrations at each point were compared between the groups.

Connect with a study center

  • Tunisia

    Nabeul, 8000
    Tunisia

    Active - Recruiting

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