Pregabalin in Treatment of Postdural Puncture Headache

Last updated: March 13, 2024
Sponsor: Al-Azhar University
Overall Status: Active - Recruiting

Phase

3

Condition

Pain

Chronic Pain

Pain (Pediatric)

Treatment

conservative treatment.

An epidural blood patch (EBP)

Pregabalin 75mg

Clinical Study ID

NCT06271486
RC. 40.5.2023
  • Ages 21-65
  • All Genders

Study Summary

Lumbar puncture (LP), often known as a "spinal tap," is a standard medical technique pioneered in the late 1900s by Heinrich Quincke. It involves the retrieval and analysis of cerebrospinal fluid (CSF) from the spinal cord, serving as the benchmark for diagnosing conditions like subarachnoid hemorrhage, meningitis, and specific neurological conditions. Pregabalin, an anticonvulsant medicine that blocks calcium entry, is used to treat a variety of diseases. It has been used to relieve pain in a variety of patient groups, including those with chronic pain, epilepsy, and anxiety disorders

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age from 21 to 65 years old,
  • both genders,
  • confirmed diagnosis of postdural puncture headache (PDPH)

Exclusion

Exclusion Criteria:

  • patient refusal
  • known allergy to the drug used in the study
  • patients with a history of convulsions
  • chronic headaches
  • contraindications to regional anesthesia (such as local infection and coagulationabnormalities).
  • Clinical indications of elevated intracranial pressure or associated risk factors
  • Deteriorated patients

Study Design

Total Participants: 75
Treatment Group(s): 3
Primary Treatment: conservative treatment.
Phase: 3
Study Start date:
February 28, 2024
Estimated Completion Date:
August 15, 2024

Connect with a study center

  • Neveen Kohaf

    Tanta, 11865
    Egypt

    Active - Recruiting

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