First Observatory of Precocious Puberty.

Last updated: January 15, 2026
Sponsor: Hospices Civils de Lyon
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06263868
69HCL23_1090
2023-A02313-42
  • Ages < 11
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The age of puberty has fluctuated throughout history. Recent data shows an increase in the age of onset of puberty signs, in the United States but also in Europe. A recent Public Health France study published in 2018 reports an increase in the incidence of precocious puberty with geographical heterogeneity. The consequences of these appearances include the early onset of menarche, short adult height and the psychological impact.

Due to a lack of studies and additional data, the reasons for this development are difficult to understand. Among current hypotheses, the entanglement with the evolution of our environment is at the forefront: the action of environmental endocrine disruptors and nutritional factors could play a role in the process of early appearance of pubertal signs.

The establishment of a national observatory for early and advanced puberty in collaboration with pediatric endocrinologists (on the front line) would allow a reliable and precise field approach, capable of supplementing epidemiological data, which are currently insufficient.

The investigators hypothesize that the establishment of an observatory of pubertal advances (early puberty and advanced puberty) in private medicine is possible, with inclusion of at least 75% of eligible patients, and collection of at least 80% of data.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Precocious puberty group (PP) :

  • Suspected precocious puberty (girl aged < 8 years or boy aged < 9 years when thefirst signs of development* appear)

  • Suspected precocious puberty (girl aged < 8 years or boy aged < 9 years when thefirst signs of development* appear)

Advanced puberty group (AP) :

  • Suspected advanced puberty (girl aged ≥ 8 and < 10 years or boy aged ≥ 9 and < 11years when the first signs of development* appear)

  • First consultation with the investigator (pediatric endocrinologist).

Control group :

  • Boy or girl without signs of pubertal development (Tanner 1);

  • Matched to the PP group on sex and age (+/- 1 year);

  • Consultation with the same investigator over the same period (same quarter) as apatient in the PP group

Exclusion

Exclusion Criteria:

All groups

  • Consultation with the same investigator over the same period (same quarter) as apatient in the PP group

  • Family not speaking French, language barrier.

Study Design

Total Participants: 3360
Study Start date:
June 26, 2024
Estimated Completion Date:
June 26, 2028

Connect with a study center

  • Clinique du Val d'Ouest

    Ecully, Auvergne-Rhône-Alpes 69130
    France

    Site Not Available

  • Clinique Saint jean

    Lyon, Auvergne-Rhône-Alpes 69008
    France

    Site Not Available

  • Pediatric practice

    Lyon, Auvergne-Rhône-Alpes 69006
    France

    Site Not Available

  • Pediatric practice

    Lyon 2996944, Auvergne-Rhône-Alpes 11071625 69006
    France

    Active - Recruiting

  • Clinique du Val d'Ouest

    Écully 3020392, Auvergne-Rhône-Alpes 11071625 69130
    France

    Active - Recruiting

  • Pediatric practice

    Rennes, Bretagne 35200
    France

    Site Not Available

  • Pediatric practice

    Rennes 2983990, Brittany Region 3030293 35200
    France

    Active - Recruiting

  • Pediatric practice

    Chambray-lès-Tours, Centre-Val De Loire 37170
    France

    Site Not Available

  • Pediatric practice

    Chambray-lès-Tours 3027343, Centre-Val de Loire 3027939 37170
    France

    Active - Recruiting

  • Pediatric practice

    Essey-lès-Nancy, Grand Est 54270
    France

    Site Not Available

  • Pediatric practice

    Essey-lès-Nancy 3019607, Grand Est 11071622 54270
    France

    Active - Recruiting

  • Pediatric practice

    Levallois-Perret, Hauts-de-Seine 92300
    France

    Site Not Available

  • Pediatric practice

    Levallois-Perret 2998975, Hauts-de-Seine 92300
    France

    Site Not Available

  • Pediatric practice

    Fondettes, Indre-et-Loire 37230
    France

    Site Not Available

  • Pediatric practice

    Fondettes 3018124, Indre-et-Loire 37230
    France

    Active - Recruiting

  • Polyclinique Bordeaux rive droite

    Lormont, Nouvelle-Aquitaine 33310
    France

    Site Not Available

  • Pediatric practice

    Pau, Nouvelle-Aquitaine 64000
    France

    Site Not Available

  • Pediatric Practice

    Pessac, Nouvelle-Aquitaine 33600
    France

    Site Not Available

  • Polyclinique Bordeaux rive droite

    Lormont 2997556, Nouvelle-Aquitaine 11071620 33310
    France

    Site Not Available

  • Pediatric practice

    Pau 2988358, Nouvelle-Aquitaine 11071620 64000
    France

    Active - Recruiting

  • Pediatric Practice

    Pessac 2987805, Nouvelle-Aquitaine 11071620 33600
    France

    Active - Recruiting

  • Clinique rive gauche

    Toulouse, Occitanie 31300
    France

    Site Not Available

  • Clinique rive gauche

    Toulouse 2972315, Occitanie 11071623 31300
    France

    Site Not Available

  • Pediatric practice

    Saint-Nazaire, Pays De La Loire 44600
    France

    Site Not Available

  • Pediatric practice

    Saint-Nazaire 2977921, Pays de la Loire Region 2988289 44600
    France

    Site Not Available

  • Pediatric practice

    Paris, Île-De-France 75010
    France

    Site Not Available

  • Pediatric practice

    Paris 2988507, Île-de-France Region 3012874 75011
    France

    Active - Recruiting

  • Pediatric practice

    Aix-en-Provence, 13090
    France

    Site Not Available

  • Pediatric practice

    Aix-en-Provence 3038354, 13090
    France

    Active - Recruiting

  • Hôpital Femme Mère Enfant, Hospices civils de Lyon

    Bron, 69677
    France

    Site Not Available

  • Hôpital Femme Mère Enfant, Hospices civils de Lyon

    Bron 3029931, 69677
    France

    Active - Recruiting

  • Pediatric practice

    Marseille, 13008
    France

    Site Not Available

  • Pediatric practice

    Marseille 2995469, 13008
    France

    Site Not Available

  • Pediatric practice

    Nice, 06000
    France

    Site Not Available

  • Pediatric practice

    Nice 2990440, 06000
    France

    Active - Recruiting

  • Clinique Saint jean

    Saint Jean de Vedas, 34430
    France

    Site Not Available

  • Clinique Saint jean

    Saint-Jean-de-Védas 2979261, 34430
    France

    Site Not Available

  • Pediatric practice

    Trélazé, 49800
    France

    Site Not Available

  • Pediatric practice

    Trélazé 2971896, 49800
    France

    Active - Recruiting

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.