First Observatory of Precocious Puberty.

Last updated: March 7, 2025
Sponsor: Hospices Civils de Lyon
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT06263868
69HCL23_1090
2023-A02313-42
  • Ages < 11
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The age of puberty has fluctuated throughout history. Recent data shows an increase in the age of onset of puberty signs, in the United States but also in Europe. A recent Public Health France study published in 2018 reports an increase in the incidence of precocious puberty with geographical heterogeneity. The consequences of these appearances include the early onset of menarche, short adult height and the psychological impact.

Due to a lack of studies and additional data, the reasons for this development are difficult to understand. Among current hypotheses, the entanglement with the evolution of our environment is at the forefront: the action of environmental endocrine disruptors and nutritional factors could play a role in the process of early appearance of pubertal signs.

The establishment of a national observatory for early and advanced puberty in collaboration with pediatric endocrinologists (on the front line) would allow a reliable and precise field approach, capable of supplementing epidemiological data, which are currently insufficient.

The investigators hypothesize that the establishment of an observatory of pubertal advances (early puberty and advanced puberty) in private medicine is possible, with inclusion of at least 75% of eligible patients, and collection of at least 80% of data.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Precocious puberty group (PP) :

  • Suspected precocious puberty (girl aged < 8 years or boy aged < 9 years when thefirst signs of development* appear)

  • Suspected precocious puberty (girl aged < 8 years or boy aged < 9 years when thefirst signs of development* appear)

Advanced puberty group (AP) :

  • Suspected advanced puberty (girl aged ≥ 8 and < 10 years or boy aged ≥ 9 and < 11years when the first signs of development* appear)

  • First consultation with the investigator (pediatric endocrinologist).

Control group :

  • Boy or girl without signs of pubertal development (Tanner 1);

  • Matched to the PP group on sex and age (+/- 1 year);

  • Consultation with the same investigator over the same period (same quarter) as apatient in the PP group

Exclusion

Exclusion Criteria:

All groups

  • Consultation with the same investigator over the same period (same quarter) as apatient in the PP group

  • Family not speaking French, language barrier.

Study Design

Total Participants: 3360
Study Start date:
June 26, 2024
Estimated Completion Date:
June 26, 2028

Connect with a study center

  • Clinique du Val d'Ouest

    Ecully, Auvergne-Rhône-Alpes 69130
    France

    Active - Recruiting

  • Clinique Saint jean

    Lyon, Auvergne-Rhône-Alpes 69008
    France

    Site Not Available

  • Pediatric practice

    Lyon, Auvergne-Rhône-Alpes 69006
    France

    Active - Recruiting

  • Pediatric practice

    Rennes, Bretagne 35200
    France

    Active - Recruiting

  • Pediatric practice

    Chambray-lès-Tours, Centre-Val de Loire 37170
    France

    Active - Recruiting

  • Pediatric practice

    Essey-lès-Nancy, Grand Est 54270
    France

    Active - Recruiting

  • Pediatric practice

    Levallois-Perret, Hauts-de-Seine 92300
    France

    Site Not Available

  • Pediatric practice

    Fondettes, Indre-et-Loire 37230
    France

    Active - Recruiting

  • Polyclinique Bordeaux rive droite

    Lormont, Nouvelle-Aquitaine 33310
    France

    Site Not Available

  • Pediatric practice

    Pau, Nouvelle-Aquitaine 64000
    France

    Active - Recruiting

  • Pediatric Practice

    Pessac, Nouvelle-Aquitaine 33600
    France

    Active - Recruiting

  • Clinique rive gauche

    Toulouse, Occitanie 31300
    France

    Site Not Available

  • Pediatric practice

    Saint-Nazaire, Pays de la Loire 44600
    France

    Site Not Available

  • Pediatric practice

    Paris, Île-De-France 75010
    France

    Active - Recruiting

  • Pediatric practice

    Aix-en-Provence, 13090
    France

    Active - Recruiting

  • Hôpital Femme Mère Enfant, Hospices civils de Lyon

    Bron, 69677
    France

    Active - Recruiting

  • Pediatric practice

    Marseille, 13012
    France

    Active - Recruiting

  • Pediatric practice

    Nice, 06000
    France

    Active - Recruiting

  • Clinique Saint jean

    Saint Jean de Vedas, 34430
    France

    Site Not Available

  • Pediatric practice

    Trélazé, 49800
    France

    Active - Recruiting

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