The Utility of Treatment With Nasogastric Tube Placement for Small Bowel Obstruction

Last updated: February 13, 2024
Sponsor: Daniel Wilhelms
Overall Status: Active - Recruiting

Phase

N/A

Condition

Ileus

Constipation

Intra-abdominal Infections

Treatment

Nasogastric tube placement

Clinical Frailty Scale

Clinical Study ID

NCT06262815
2023-06806-01
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Small bowel obstruction (SBO) occurs when the normal movements of the small bowel is obstructed, most commonly due to adhesion related to previous abdominal surgery. This may cause strangulation of the small bowel with reduced blood flow which is a surgical emergency requiring prompt treatment in the operating room. If there are no signs of strangulation or ischemia of the bowel at the time of diagnosis, international guidelines recommend initial treatment with intravenous fluids and nasogastric tube placement. However, there is emerging debate regarding non-selective treatment with nasogastric tube placement in patients with SBO. This management started around 1930 as a means to reduce pain in patients with SBO, in conjunction with other additions to management, like intravenous fluids. However the effect and utility of routine nasogastric tube placement have not been prospectively evaluated. There are a total of three retrospective observational studies in the past decade with a total of 759 patients where 292 (36%) were managed without a nasogastric tube. There was no difference in the rates of conservative treatment failure (requiring surgery), complications (vomiting, pneumonia) or mortality between patients receiving a nasogastric tube and those who didn't. However, the retrospective design of these studies limits their validity. Furthermore, nasogastric tube placement has been shown to be one of the more painful interventions patients may experience in-hospital. This calls into question the patient benefit of routine nasogastric tube placement in patients with SBO and further studies are needed to discern the utility of this intervention.

Definitive treatment for SBO is surgical adhesiolysis but there is debate regarding the timing of surgery, particularly in older adults. A large proportion of patients may be managed conservatively with oral contrast and repeated radiological evaluation and the obstruction will resolve in many patients within 24 to 48 hours. This timeframe is dependent on factors related to the disease itself as well as patient related factors like previous surgery and comorbidities. Older patients are at high risk for complications but current available data is insufficient to inform practice in this population. Frailty, a state of increased vulnerability and susceptibility to adverse events, has been shown to be an independent prognosticator in older adults in the Emergency Department(ED) and suggested as a potential measure to risk stratify older adults with SBO. However to the authors knowledge there is no available data on frailty in older adults with SBO and only one prospective observational trial looking at older adults with SBO. Despite SBO being one of the most common surgical emergencies in older adults.

To investigate the potential benefit of nasogastric tube placement in patients with SBO and the ability of frailty to prognosticate outcomes in older adults better evidence is needed.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosed small bowel obstruction
  • Age 18 or older

Exclusion

Exclusion Criteria:

  • Abdominal surgery within 7 days
  • Not able to give informed consent

Study Design

Total Participants: 400
Treatment Group(s): 2
Primary Treatment: Nasogastric tube placement
Phase:
Study Start date:
January 01, 2024
Estimated Completion Date:
December 31, 2024

Connect with a study center

  • Akutmottagningen US Östergötland

    Linköping, Östergötland 58185
    Sweden

    Active - Recruiting

  • Sahlgrenska Universitetssjukhuset

    Göteborg,
    Sweden

    Active - Recruiting

  • Östra sjukhuset

    Göteborg,
    Sweden

    Active - Recruiting

  • Skånes Universitetssjukhus

    Lund,
    Sweden

    Site Not Available

  • Skånes Universitetssjukhus

    Malmö,
    Sweden

    Site Not Available

  • Lasarett i Motala

    Motala,
    Sweden

    Active - Recruiting

  • Vrinnevisjukhuset

    Norrköping,
    Sweden

    Active - Recruiting

  • Sundsvalls sjukhus

    Sundsvall,
    Sweden

    Active - Recruiting

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