Detection of Cancer in Breath Samples by Trained Detection Dogs

Last updated: May 13, 2026
Sponsor: SpotitEarly
Overall Status: Completed

Phase

N/A

Condition

Colorectal Cancer

Colon Cancer

Prostate Cancer

Treatment

N/A

Clinical Study ID

NCT06255041
SIE-001
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this study is to show that trained detection dogs can identify breast, lung, prostate or colorectal cancer by sniffing masks containing breath samples. In this study, individuals who will undergo cancer screening at an integrated cancer prevention center or biopsy for a suspected malignancy, will be asked to provide a breath sample by breathing into a surgical mask. The mask will then be sent to the laboratory, where trained detection dogs will determine if the person who provided the mask has breast, lung, prostate or colorectal cancer or if the person does not have these types of cancer. The results provided by the dogs will be compared to the actual cancer screening results or biopsy results in order to determine the accuracy of cancer detection by the trained dogs.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Men and women aged 18 and over.

  2. Signing an informed consent prior to performing the test.

  3. Intended to undergo screening tests for cancer detection.

  4. Did not smoke 2 hours before providing the breath sample

  5. Did not drink coffee in the hour before providing the breath sample

  6. Did not drink an alcoholic beverage in the hour prior to providing the breathsample.

  7. Did not eat food in the hour before providing the breath sample.

Exclusion

Exclusion Criteria:

  1. Was diagnosed with cancer or was treated for cancer in the seven years preceding thestudy, excluding non-metastatic skin tumors that were surgically removed.

  2. Undergoing chemotherapy for any purpose.

  3. Pregnant or breastfeeding

  4. Had a medical procedure in the chest cavity and/or airways in the two weeks prior toproviding the breath sample that may interfere with the ability to correctly providea breath sample.

  5. Has a Helicobacter pylori infection.

  6. Has a peptic ulcer disease.

  7. Has a flare-up of an inflammatory bowel disease (Crohn's disease/ulcerativecolitis).

  8. has an active infection, such as COVID-19, abscess, bacterial/viral/fungalinfection, pneumonia, laryngitis, intestinal inflammation, active tuberculosisinfection.

Study Design

Total Participants: 1386
Study Start date:
February 10, 2021
Estimated Completion Date:
January 31, 2024

Connect with a study center

  • Rambam Health Care Campus

    Haifa,
    Israel

    Site Not Available

  • Tel Aviv Sourasky Medical Center

    Tel Aviv,
    Israel

    Site Not Available

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