Effect of Tourniquet Binding of Cervical on the Blood Volume of Amniotic Fluid in Cesarean Section

Last updated: February 8, 2024
Sponsor: First People's Hospital of Chenzhou
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Scleroderma

Blood Clots

Deep Vein Thrombosis

Treatment

tourniquet binding of cervical

Clinical Study ID

NCT06254092
2023121
  • Ages 20-45
  • Female
  • Accepts Healthy Volunteers

Study Summary

This study was conducted to investigate whether the use of tourniquet after delivery of the fetus could reduce the amount of amniotic fluid entering the bloodstream and thus reduce the incidence of intraoperative adverse events.

Eligibility Criteria

Inclusion

Inclusion criteria

  1. Single pregnancy

  2. Be in good health, with no high blood pressure or heart disease during pregnancy

  3. Without placenta previa and placenta implantation

  4. No abdominal adhesions, suitable for operation

  5. Signed informed consent by the pregnant woman and her family

Exclusion criteria

  1. Serious coagulation abnormality

  2. Preoperative severe cardiac, cerebral, pulmonary, hepatic, renal and other important organs insufficiency and electrolyte abnormality combined with placenta praevia or placenta implantation

  3. Multiple pregnancies

  4. Previous history of abdominal surgery

  5. Intraoperative drug allergy

Study Design

Total Participants: 28
Treatment Group(s): 1
Primary Treatment: tourniquet binding of cervical
Phase:
Study Start date:
January 31, 2024
Estimated Completion Date:
August 01, 2024

Study Description

Amniotic fluid embolism (AFE) is a rare complication specially to obstetrics.When amniotic fluid enters the maternal circulation , a sudden onset of a series of pathophysiologic changes such as pulmonary hypertension, hypoxemia, circulatory failure, disseminated intravascular coagulation, and multiorgan failure may occur. Routinely, the typical AFE triad is uneasy to discover, and nonspecific adverse reactions such as irritability, chills, chest tightness and shortness of breath, transient drop in blood pressure, and nausea and vomiting are often seen during delivery of the fetus and placenta. All of the above symptoms may suggest that the amniotic fluid has entered into the bloodstream. In clinical anesthesia, investigators observed that women with placenta praevia and placenta implantation were less likely to suffer these nonspecific symptoms after delivery of the fetus compared with women with normal pregnancies.The investigators speculated it might be related to the fact that obstetricians used tourniquets to reduce intraoperative hemorrhage in the former, blocking venous return to the lower uterine segments to reduce the inflow of amniotic fluid into the uterus. Therefore, this study was conducted to investigate whether the use of tourniquet after delivery of the fetus could reduce the amount of amniotic fluid entering the bloodstream and thus reduce the incidence of intraoperative adverse events.

Connect with a study center

  • Zhiming Zhang

    Chenzhou, Hunan 423000
    China

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.