Effects of Dietary Polystyrene Microplastics on Anxiety- and Depression-like Behaviors

Last updated: August 21, 2024
Sponsor: Northern Jiangsu People's Hospital
Overall Status: Completed

Phase

N/A

Condition

Panic Disorders

Depression

Anxiety Disorders

Treatment

Dietary polystyrene microplastics from disposable plastic tableware

Clinical Study ID

NCT06247579
Dietary
  • Ages 20-30
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The objective of this clinical trial is to explore the potential impact of dietary polystyrene microplastics on anxiety- and depression-like behaviors in resident physicians. Specifically, the study aims to address two key questions:

  1. Can dietary polystyrene microplastics induce alterations in the human gut microbiome?

  2. Can dietary polystyrene microplastics exacerbate anxiety- and depression-like behaviors?

Participants will be divided into two groups based on their habitual eating practices: The control group, consisting of resident physicians, will use non-disposable plastic tableware (NDPT) provided by hospital canteens for two months. In contrast, the exposure group, also comprising resident physicians, will use disposable plastic tableware (DPT) made of polystyrene, provided by the same hospital canteens, over the same period.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Volunteer resident physician at the base of Northern Jiangsu Hospital, Yangzhou,China

Exclusion

Exclusion Criteria:

  • received chemotherapy, radiotherapy, or surgery in the 3 -6 months before sampling

  • diagnosed with mental illness

  • diagnosed with digestive system diseases

Study Design

Total Participants: 15
Treatment Group(s): 1
Primary Treatment: Dietary polystyrene microplastics from disposable plastic tableware
Phase:
Study Start date:
January 01, 2024
Estimated Completion Date:
May 01, 2024

Study Description

The mental health and well-being of resident physicians is a critical topic that has gained increasing attention recently. Recent studies have shown a growing prevalence of mental health illnesses worldwide. For medical trainees and resident physicians, high rates of depression, anxiety, suicidal ideation, and burnout have been consistently observed. Moreover, contemporary research suggests that dietary exposure plays a pivotal role in the development of mental illnesses. Disposable plastic tableware, commonly used during resident training programs, could be a contributing factor. However, the specific effects of dietary exposure from such tableware on mental health, particularly through the gut-brain axis, remain largely unexplored. Consequently, investigating the potential impact of dietary polystyrene microplastics on anxiety- and depression-like behaviors in resident physicians is essential.

Connect with a study center

  • Ju Gao

    Yangzhou, Jiangsu 225001
    China

    Site Not Available

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