Evaluation of Sinus Augmentation Bone Healing Using Autograft and Xenograft Compared to Xenograft Alone

Last updated: November 18, 2024
Sponsor: Tufts University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dental Filling

Treatment

Cone-beam computed tomography systems (CBCT)

Sinus Lift augmentation

Clinical Study ID

NCT06247098
STUDY00004629
  • Ages > 18
  • All Genders

Study Summary

To evaluate bone healing at 4 months after lateral sinus augmentation with a 4:1 ratio of autologous bone and xenograft or xenograft alone. A radiographic volumetric, histomorphometric, and histologic analysis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients of Tufts School of Dental Medicine (TUSDM)

  • Two stage sinus augmentations with <5mm (Zinner, Small 2004) residual bone height inneed of augmentation for implant placement

  • Full maxillary edentulism or Kennedy class I or III

  • 18 to 100 year old

Exclusion

Exclusion Criteria:

  • Adults unable to consent (cognitively impaired adults)

  • Those who self-report as pregnant or breastfeeding

  • Wards of the state

  • Non-Viable neonates

  • Neonates of uncertain viability

  • < 18 years of age

  • Refusal to participate

  • Prior medical condition causing complications in bone metabolism

  • Osteoporosis

  • History of/or current chemotherapy

  • History of/or current head and neck radiation

  • Current heavy smoking > 10 cigarettes/day

  • Self-reported pregnancy or lactation

  • Previous history of sinus elevation procedure

  • Existing sinus pathology or pathology discovered at time of sinus augmentation orimplant placement

  • Absence of autogenous donor site

Study Design

Total Participants: 10
Treatment Group(s): 2
Primary Treatment: Cone-beam computed tomography systems (CBCT)
Phase:
Study Start date:
September 01, 2024
Estimated Completion Date:
May 31, 2028

Connect with a study center

  • Tufts University School of Dental Medicine

    Boston, Massachusetts 02111
    United States

    Active - Recruiting

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