A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

Key Inclusion Criteria:

1. Participants with histologically confirmed unresectable stage III and stage IV (metastatic) melanoma per American Joint Committee on Cancer (AJCC), eighth revisededition.

2. Participants must not have received prior systemic therapy for unresectable ormetastatic melanoma as described in the protocol.

3. Measurable disease per RECIST version 1.1.

4. Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤1

5. Adequate bone marrow, hepatic, and kidney function

6. Known B-Rapidly Accelerated Fibrosarcoma protein (BRAF) V600 mutation status orsubmitted sample for BRAF V600 mutation assessment as described in the protocol

Key Exclusion Criteria:

Medical Conditions:

1. Uveal, acral or mucosal melanoma.

2. Ongoing or recent (within 2 years) evidence of an autoimmune disease that requiredsystemic treatment with immunosuppressive agents as described in the protocol.

3. Uncontrolled infection with human immunodeficiency virus (HIV), hepatitis B (HBV),or hepatitis C virus (HCV) infection; or diagnosis of immunodeficiency that isrelated to, or results in chronic infection. Mild cancer-related immunodeficiency (such as immunodeficiency treated with gamma globulin and without chronic orrecurrent infection) is allowed. Prior/Concomitant Therapy:

4. Prior immune checkpoint inhibitor therapy other than anti-PD1/PD-L1 as described inthe protocol

5. Systemic immune suppression as described in the protocol. Other Comorbidities:

6. Participants with a history of myocarditis.

7. Troponin T (TnT) or troponin I (TnI) >2x institutional upper limit of normal (ULN).

8. Active or untreated brain metastases or spinal cord compression as described in theprotocol.

Note: Other protocol-defined Inclusion/ Exclusion Criteria apply.