Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema

Last updated: January 24, 2024
Sponsor: Chang Gung Memorial Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lymphedema

Treatment

Patients underwent lymphedema surgery

Patients underwent surgery without LVA

Clinical Study ID

NCT06237907
202201327B0
  • Ages 20-100
  • All Genders

Study Summary

The project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Control Group: Patients who have not experienced lymphedema but require surgery due toother diseases such as cancer, trauma, chronic wounds, skin defects, etc.
  • Experimental Group: Patients who have lymphedema and undergone lymphedema surgery.

Exclusion

Exclusion Criteria:

    1. Individuals with venous thrombosis, chronic heart failure, and renal failure.
    1. Vulnerable populations, individuals with limited mobility, pregnant women, andminors.
    1. Those expected to be unable to attend follow-up visits or complete the studysmoothly.
    1. Participants who express doubts about the trial and cannot provide satisfactoryanswers.

Study Design

Total Participants: 120
Treatment Group(s): 2
Primary Treatment: Patients underwent lymphedema surgery
Phase:
Study Start date:
September 20, 2023
Estimated Completion Date:
January 12, 2026

Study Description

This project aims to investigate the expression of cell death through apoptosis and iron-dependent cell death in the subcutaneous adipose tissue of patients with lymphedema. The study also seeks to explore the roles of these processes among lymphatic endothelial cells, adipocytes, and macrophages, and their association with lymphedema, thus gaining insights into the pathophysiological mechanisms of lymphedema. Furthermore, the project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

Connect with a study center

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung, 83301
    Taiwan

    Active - Recruiting

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