European Myeloma Network (EMN) Sample Project

Inclusion Criteria:

• Subjects with MGUS, smouldering Multiple Myeloma (SMM) , MM (Multiple Myeloma) (+/-EMD), plasma cell leukemia (PCL) (+/- EMD)

• Subjects are ≥ 18 years old.

• Subjects have provided written informed consent in accordance with federal, local,and institutional guidelines prior to initiation of any project-specific activitiesor procedures.

1. Subjects do not have kind of condition that, in the opinion of theInvestigators, may compromise the ability of the subjects to give writteninformed consent and

2. subjects are, in the investigator's opinion, willing and able to comply withthe protocol requirements.

Exclusion Criteria:

• Previous treatment with anti-myeloma therapy (excluding one course of therapy inpatients in which urgent therapy is deemed necessary according to physician'sdiscretion, e.g. myeloma-related complications resistant to supportive care).

• Subjects have had prior unforeseen (serious) adverse reactions to blood donationincluding, but not limited to fainting, angina, severe bruising, allergic reactions,or any other adverse events.

• Any psychological, familial, sociological and geographical condition potentiallyhampering compliance with the protocol and follow-up schedule.