A Study of ZG19018 in Patients With KRAS G12C Mutant Advanced Solid Tumors.

Last updated: January 23, 2024
Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Overall Status: Active - Recruiting

Phase

1/2

Condition

Neoplasms

Treatment

ZG19018

Clinical Study ID

NCT06237400
ZG19018-001
  • Ages > 18
  • All Genders

Study Summary

Evaluate the safety and tolerability of ZG19018 in Patients with KRAS G12C mutant advanced solid tumors.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Subjects who fully understood this trial and voluntarily signed the informed consentform;
  • Men or women ≥ 18 years old;
  • ECOG Performance Status (PS) 0 or 1;
  • Life expectancy > 3 months.

Exclusion

Exclusion Criteria:

  • Received any treatment with inhibitors against KRAS G12C mutation at any time, e.g.,AMG 510, MRTX 849, etc.;
  • Patients requiring medications that can potentially prolong QTc interval;
  • Other conditions that the investigator considers to be unsuitable for participation inthis study.

Study Design

Total Participants: 110
Treatment Group(s): 1
Primary Treatment: ZG19018
Phase: 1/2
Study Start date:
May 26, 2022
Estimated Completion Date:
May 31, 2025

Connect with a study center

  • Chinese PLA General Hospital

    Beijing, Beijing 100853
    China

    Active - Recruiting

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