Phase
Condition
Neoplasms
Treatment
LY3537982
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Native Chinese participants must be of an acceptable age to provide informedconsent.
Have measurable disease per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST version 1.1).
Have disease with evidence of KRAS G12C mutation
Have a histologically or cytologically proven diagnosis of locally advanced,unresectable, and/or metastatic cancer and must be appropriate candidates for studytreatment.
Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
Have adequate laboratory parameters.
Must be able to swallow capsules or tablets.
Estimated life expectancy ≥12 weeks
Exclusion
Exclusion Criteria:
Have disease suitable for local therapy administered with curative intent.
Have an active fungal, bacterial, and/or active untreated viral infection,
Have a serious pre-existing medical condition(s) that would preclude participationin this study.
Have a serious cardiac condition.
Have untreated active symptomatic central neural system (CNS) malignancy ormetastasis and/or carcinomatous meningitis.
Have received prior treatment with any KRAS G12C small molecule inhibitor.
Females who are pregnant or lactating.
Have a known allergic reaction against any of the components of the study drug
Study Design
Connect with a study center
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang 150081
ChinaSite Not Available
Hunan Cancer Hospital
Changsha, Hunan 410013
ChinaSite Not Available
Jilin Cancer Hospital
Changchun, Jilin 132000
ChinaSite Not Available
Jilin Province Tumor Hospital
Changchun, Jilin 130028
ChinaSite Not Available
Jinan Central Hospital
Jinan, Shandong 250013
ChinaSite Not Available
Shanghai Chest Hospital
Shanghai, Shanghai 200030
ChinaSite Not Available
The First Affiliated Hospital, Zhejiang University
Hangzhou, Zhejiang 310003
ChinaSite Not Available
The first Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang 310003
ChinaSite Not Available
Zhejiang Cancer Hospital
Hangzhou, Zhejiang 310022
ChinaSite Not Available
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