Periodontitis, a common inflammatory dis ease, affects the teeth-supporting tissues. In this
complex disease, dental biofilm interacts with inflammatory immune system, which may lead to
an imbalance between bacterial invasion and the intensity of the host immune response.
Scaling and root planning (SRP) is a common major meth od used as the gold standard for
periodontal treatment. However, SRP alone has limited effects on some bacterial species and
does not remove subgingival bacteria completely. This may be related to the fact that some
species may exist in soft tissue, dentinal tubules, or root surface irregularities, which are
associated with the treatment failure.
Therefore, to help the healing process, both chemical and herbal therapeutic mouthwashes were
added to the treatment. In this way, herbs such as turmeric with its potent anti-inflammatory
active ingredient, curcumin, or ginger have been used as adjunctive treatment for
periodontitis along with SRP. In traditional Persian medicine, saffron and its extracts are
used to improve digestion, increase appetite, relaxation, and treat liver diseases, spasm,
toothache, rhinitis, pharyngitis, insomnia, depression, cough, asthma, bronchitis, fever,
nausea, scarlet fever, urinary tract infections, cardiovascular disorders, and even cancers
and immune system modulation. According to the modern studies, saffron has antioxidant,
anti-inflammatory, anticoagulant, antibacterial and analgesic effects.
In recent years, herbal plants have received increasing attention considering their roles in
health and disease. Saffron (Crocus sativus, L.) is an example of herbs, commonly used as a
flavoring agent in food preparation. Saffron contains high amounts of carotenoid pigments
(crocin, crocetin, α-carotene, lycopene, and zeaxanthin), monoterpene aldehydes (picrocrocin
and safranal), monoterpenoids (crocusatines), isophorones, and flavonoids, which could
contribute to its wide range of biological properties. A number of investigations have shown
that saffron possesses anti-oxidant, anti-tumor, anti-genotoxic, and hypotensive properties.
In addition, a growing number of studies have suggested that saffron possesses
anti-inflammatory properties too.
However, clinical studies are very limited about the use of saffron in the field of oral
diseases. A laboratory study reported that ethyl acetate extract of saffron has strong
antimicrobial effects against various microorganisms such as both gram-positive (g+) and
gram-negative (g-) bacteria, but it is obvious that alcoholic compounds themselves may have
an antibacterial effect, so to avoid errors, the investigators chose the aqueous type from
two types of alcoholic and aqueous extracts.
Considering the anti-inflammatory effect of saffron and due to the dissatisfaction of some
patients with the taste of conventional mouthwashes, especially the gold standard
chlorhexidine, this study was conducted to investigate the effect of mouthwash containing
saffron aqueous extract on periodontal indices of patients with moderate to severe
generalized periodontitis.
