Manage Macular Cystoid Edema with Retinal Vein Obstruction Using Traditional Chinese Medicine and Ranibizumab

Last updated: December 12, 2024
Sponsor: Dongyang People's Hospital
Overall Status: Active - Recruiting

Phase

4

Condition

Cystoid Macular Edema

Treatment

Jueling Mingmu decoction

intravitreal injections of 0.5mg ranibizumab

Clinical Study ID

NCT06234514
JQMMT
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The objective of this study was to investigate the efficacy and safety of traditional Chinese medicine (Jueling Mingmu Decoction) combined with ranibizumab in the treatment of macular edema with retinal vein obstructive.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Foveal center-involved macular edema (ME) lasting less than 9 months

  • Central Macular Thickness (CMT) greater than or equal to 250 μm

  • Best-Corrected Visual Acuity (BCVA) of 24-73 letters (20/40 to 20/320) in the studyeye

  • Initial diagnosis with no prior treatments, such as laser therapy or intravitrealinjections

Exclusion

Exclusion Criteria:

  • Presence of any additional macular pathology, such as age-related maculardegeneration (AMD) or diabetic retinopathy (DR) affecting the macula

  • Concurrent serious conditions, such as cardiovascular diseases, liver, or kidneydiseases

  • Concerns or doubts regarding treatment

  • Known allergies to the ingredients of the medication.

Study Design

Total Participants: 100
Treatment Group(s): 2
Primary Treatment: Jueling Mingmu decoction
Phase: 4
Study Start date:
January 01, 2023
Estimated Completion Date:
May 31, 2025

Study Description

Compared to the sole intravitreal injection of ranibizumab, the combined use of traditional Chinese medicine with intravitreal ranibizumab aims to determine if it is more effective in alleviating macular cystoid edema secondary to retinal branch vein occlusion, leading to improved visual prognosis and potentially reducing the frequency of intravitreal drug injections.

Connect with a study center

  • Dongyang People's Hospital

    Dongyang, Zhejiang 322100
    China

    Active - Recruiting

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