Muscle Fatigability and Trip-specific Fall Risk in Adults With Knee Osteoarthritis

Phase

N/A

Condition

Pain (Pediatric)

Osteoarthritis

Treatment

30 minute treadmill walk

Clinical Study ID

NCT06229691

1924071

U54GM104941

Ages 55-70
All Genders
Accepts Healthy Volunteers

Study Summary

The goal of this clinical trial is to learn about how fatigue affects the risk of falling in adults aged 55-70 years with and without knee osteoarthritis. The main questions this trial aims to answer are:

Does fatigue increase the risk of tripping while walking? and
Does fatigue increase the risk of falling in response to a trip while walking? Participants will
Complete questionnaires
Wear a device that measures physical activity for 5-7 days
Complete a 30 minute walk on a treadmill
Complete the following before and after the treadmill walk:
- Computer test to measure mental fatigue
- Maximal strength testing
- Balance test

Researchers will compare adults with and without knee osteoarthritis to see if fall risk in adults with knee osteoarthritis is affected more by walking activity compared to adults without knee osteoarthritis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

For adults with knee osteoarthritis:

presence of occasional to frequent knee pain
knee pain that is primarily in the medial knee joint compartment
minimal morning joint stiffness

For all participants:

able to walk continuously for 30 minutes without an assistive device

Exclusion

Exclusion Criteria:

fracture or surgery within 1 year
history of joint replacement
lower-extremity joint injections within 3 months
history of stroke or other neurological condition
cardiovascular or pulmonary conditions that limit daily activity or that precludeparticipation in exercise
history of major lower extremity or back injury or pain (except for kneeosteoarthritis)
history of lower extremity amputation
use an orthotic or prosthetic to walk
use of beta blockers or other medications that affect fatigue
use of medications that affect balance
diabetic neuropathy
acute illness or the presence of lesions on the torso or lower extremities
BMI greater than 35
body weight over 265 lbs

Study Design